Harvard School of Public Health AIDS Initiative

 

Research Papers - Recent Papers

 

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2012

Wester, C.W., Stitelman, O.M., Degruttola, V., Bussmann, H., Marlink, R.G., van der Laan, M.J. Effect Modification by Sex and Baseline CD4+ Cell Count Among Adults Receiving Combination Antiretroviral Therapy in Botswana: Results from a Clinical Trial. AIDS Res Hum Retroviruses. 2012 Feb 6. [Epub ahead of print]

Dong, B.J., Zheng, Y., Hughes, M.D., Frymoyer, A., Verotta, D., Lizak, P., Sawe, F., Currier, J.S., Lockman, S., Aweeka, F.T.; for the AIDS Clinical Trials Group Study 5208 Team. Nevirapine (NVP) pharmacokinetics (PK) and risk of rash and hepatitis among HIV-infected Sub-Saharan African Women. AIDS. 2012 Feb 1. [Epub ahead of print]

Laeyendecker, O., Brookmeyer, R., Mullis, C., Donnell, D., Lingappa, J., Celum, C., Baeten, J.M., Campbell, M.S., Essex, M., de Bruyn, G., Farquhar, C., Quinn, T.C., Eshleman, S. Specificity of four laboratory approaches for cross-sectional HIV incidence determination: Analysis of samples from adults with known non-recent HIV infection from five African countries. AIDS Res Hum Retroviruses. 2012 Jan 29. [Epub ahead of print]

Novitsky, V., Essex, M. Using HIV viral load to guide treatment-for-prevention interventions. Curr Opin HIV AIDS. 2012 Jan 16. [Epub ahead of print]

Lockman, S., Sax, P. Treatment-for-prevention: clinical considerations. Curr Opin HIV AIDS. 2012 Jan 5. [Epub ahead of print]


2011

Armstrong, K.L., Lee, T.H., Essex, M. The Replicative Fitness Costs of Non-Nucleoside Reverse Transcriptase Inhibitor Drug Resistance Mutations on HIV Subtype C. Antimicrob Agents Chemother. 2011 Mar 14. [Epub ahead of print]

Agaba. P.A., Digin, E., Makai, R., Apena, L., Agbaji, O.O., Idoko, J.A., Murphy, R., Kanki, P. Clinical characteristics and predictors of mortality in hospitalized HIV-infected Nigerians. J Infect Dev Ctries. May 28;5(5):377-82. (2011)

Baeten, J.M., Lingappa, J., Beck., I., Freukel, L., Pepper, G., Wald, A., Fife, K., Were, E., Mugo, N., Sanchez, J., Essex, M., Makhema, J., Kiare, J., Farquhar, C., Corey, L., and Celum, C. Herpes Simplex Virus Type 2 Suppressive Therapy with Acyclovir or Valacyclovir Does Not Select for Specific HIV-1 Resistance in HIV 1/HSV-2 Dually Infected Persons. J. Infect. Dis. 203:117–21 (2011).

Brown, B.J., Oladokun, R.E., Osinusi, K., Ochigbo, S., Adewole, I.F., Kanki, P. Disclosure of HIV status to infected children in a Nigerian HIV Care Programme. AIDS Care. Apr 5:1-6 (2011) [Epub ahead of print]

Bussmann, H., de la Hoz Gomez, F., Roels, T.H., Wester, C.W., Bodika, S.M., Moyo, S., Taffa, N., Anderson, M.G., Mine, M., Bile, E.C., Yang, C., Mphoyakgosi, K., Lehotzky, E.A., Mlotshwa, B., Mmelesi, M., Seipone, K., Makhema, M.J., Marlink, R.G., Novitsky, V., Essex, M. Prevalence of transmitted HIV drug resistance in Botswana: lessons learned from the HIVDR-Threshold Survey conducted among women presenting for routine antenatal care as part of the 2007 national sentinel survey. AIDS ResHum Retroviruses. Apr;27(4):365-72. (2011)

Ciaranello, A.L., Lockman, S., Freedberg, K.A., Hughes, M., Chu, J., Currier, J., Wood, R., Holmes, C.B., Pillay, S., Conradie, F., McIntyre, J., Losina, E., Walensky, R.P. for the CEPAC-International and OCTANE Investigators. First-line antiretroviral therapy after single-dose nevirapine exposure in South Africa: a cost-effectiveness analysis of the OCTANE trial. AIDS. 25:479–92. (2011)

Cohen, M.S., Chen, Y.Q., McCauley, M., Gamble, T., Hosseinipour, M.C., Kumarasamy, N., Hakim, J.G., Kumwenda, J., Grinsztejn, B., Pilotto, J.H., Godbole, S.V., Mehendale, S., Chariyalertsak, S., Santos, B.R., Mayer, K.H., Hoffman, I.F., Eshleman, S.H., Piwowar-Manning, E., Wang, L., Makhema, J., Mills, L.A., de Bruyn, G., Sanne, I., Eron, J., Gallant, J., Havlir, D., Swindells, S., Ribaudo, H., Elharrar, V., Burns, D., Taha, T.E., Nielsen-Saines, K., Celentano, D., Essex, M., Fleming, T.R.; the HPTN 052 Study Team. Prevention of HIV-1 Infection with Early Antiretroviral Therapy. N Engl J Med. 2011 Jul 18. [Epub ahead of print]

Dryden-Peterson, S., Shapiro, R.L., Hughes, M.D., Powis, K., Ogwu, A., Moffat, C., Moyo, S., Makhema, J., Essex, M., Lockman, S. Increased Risk of Severe Infant Anemia Following Exposure to Maternal HAART, Botswana. JAIDS. Jan 25. Epub ahead of print. (2011)

Dryden-Peterson, S., Jayeoba, O., Hughes, M.D., Jibril, H., Keapoletswe, K., Tlale, J., Modise, T.A., Asmelash, A., Moyo, S., van Widenfel,t E., Makhema, J., Essex, M., Shapiro, R.L., Lockman, S. Highly Active Antiretroviral Therapy versus Zidovudine for Prevention of Mother-to-Child Transmission in a Programmatic Setting, Botswana. J Acquir Immune Defic Syndr. 2011 Jul 22. [Epub ahead of print]

Firnhaber, C., Evans, D., Friedman-Khalili, R., Willliams, S., Michelow, P., Matlhagela, K., Wester, C., Grinsztejn, B., Lockman, S. Seroprevalence of HPV vaccine types 6, 11, 16 and 18 in HIV-infected women from South Africa, Brazil and Botswana. J Clin Virol. 2011 Sep 9. [Epub ahead of print]

Heidari, S., Mofenson, L.M., Hobbs, C.V., Cotton, M.F., Marlink, R., Katabira, E. Unresolved Antiretroviral Treatment Management Issues in HIV-Infected Children. J Acquir Immune Defic Syndr. 2011 Dec 1. [Epub ahead of print]

Jayeoba, O., Dryden-Peterson, S., Okui, L., Smeaton, L., Magetse, J., Makori, L., Modikwa, V., Mogodi, M., Plank, R., Lockman, S. Acceptability of Male Circumcision Among Adolescent Boys and their Parents, Botswana. AIDS Behav. Mar 25 (2011). [Epub ahead of print]

Lin, N.H., Smeaton, L.M., Giguel, F., Novitsky, V., Moyo, S., Mitchell, R.M., Makhema, J., Essex, M., Lockman, S., and Kuritzkes, D.R. Prevalence and clinical associations of CXCR4-using HIV-1 among treatment-naive subtype C-infected women in Botswana. JAIDS. Feb 21. Epub ahead of print. (2011)

Lingappa, J.R., Petrovski, S., Kahle, E., Fellay, J., Shianna, K., McElrath, M.J., Thomas, K.K., Baeten, J.M., Celum, C., Wald, A., de Bruyn, G., Mullins, J.I., Nakku-Joloba, E., Farquhar, C., Essex, M., Donnell, D., Kiarie, J., Haynes, B., Goldstein, D.; for the Partners in Prevention HSV/HIV Transmission Study Team .Genomewide Association Study for Determinants of HIV-1 Acquisition and Viral Set Point in HIV-1 Serodiscordant Couples with Quantified Virus Exposure. PLoS One. 2011;6(12):e28632. Epub 2011 Dec 12.

Matthews, L.T., Ribaudo, H.J., Parekh, N.K., Chen, J.Y., Binda, K., Ogwu, A., Makhema, J., Souda, S., Lockman, S., Essex, M., Shapiro, R.L. Birth weight for gestational age norms for a large cohort of infants born to HIV-negative women in Botswana compared with norms for U.S-born black infants. BMC Pediatr. 2011 Dec 16;11(1):115. [Epub ahead of print]

Novitsky, V., Wang, R., Margolin, L., Baca, J., Rossenkhan, R., Moyo, S., van Widenfelt, E., and Essex, M. Transmission of Single and Multiple Viral Variants in Primary HIV-1 Subtype C Infection. PLoS One. 6:e16714 (2011).

Novitsky, V., Ndung'u, T., Wang, R., Bussmann, H., Chonco, F., Makhema, J., De Gruttola, V., Walker, B.D., Essex, M. Extended high viremics: a substantial fraction of individuals maintain high plasma viral RNA levels after acute HIV-1 subtype C infection. AIDS. Apr 18. (2011). [Epub ahead of print].

Novitsky, V., Wang, R., Baca, J., Margolin, L., McLane, MF., Moyo, S., van Widenfelt, E., Makhema, J., Essex, M. Evolutionary gamut of in vivo Gag substitutions during early HIV-1 subtype C infection. Virology. 2011 Oct 17. [Epub ahead of print]

Parekh, N., Ribaudo, H., Souda, S., Chen, J., Mmalane, M., Powis, K., Essex, M., Makhema, J., Shapiro, R.L. Risk factors for very preterm delivery and delivery of very-small-for-gestational-age infants among HIV-exposed and HIV-unexposed infants in Botswana. Int J Gynaecol Obstet. 2011 Jul 16. [Epub ahead of print]

Porter, K.A., Cole, S.R., Eron, J.J. Jr, Zheng, Y., Hughes, M.D., Lockman, S., Poole, C., Skinner-Adams, T.S., Hosseinipour, M., Shaffer, D., D'Amico, R., Sawe, F.K., Siika, A., Stringer, E., Currier, J.S., Chipato, T., Salata, R., McCarthy, J.S., Meshnick, S.R. HIV-1 protease inhibitors and clinical malaria: A secondary analysis of ACTG A5208. Antimicrob Agents Chemother. 2011 Nov 28. [Epub ahead of print]

Powis, K.M., Smeaton, L., Ogwu, A., Lockman, S. Dryden-Peterson, S., van Widenfelt, E., Leidner, J., Makhema, J., Essex, M., and Shapiro, R.L. Effects of in utero antiretroviral exposure on longitudinal growth of HIV-exposed uninfected infants in Botswana. JAIDS. 1:56(2):131–8. (2011)

Powis, K.M., Kitch, D., Ogwu, A., Hughes, M.D., Lockman, S., Leidner, J., van Widenfelt, E., Moffat, C., Moyo, S., Makhema, J., Essex, M., Shapiro, R.L. Increased Risk of Preterm Delivery Among HIV-Infected Women Randomized to Protease Versus Nucleoside Reverse Transcriptase Inhibitor-Based HAART During Pregnancy. J Infect Dis. 2011 Aug;204(4):506-14.

Rawizza, H.E., Chaplin, B., Meloni, S.T., Eisen, G., Rao, T., Sankalé, J.L., Dieng-Sarr, A., Agbaj,i O., Onwujekwe, D.I., Gashau, W., Nkado, R., Ekong, E., Okonkwo, P., Murphy, R.L., Kanki, P.J.; for the APIN PEPFAR Team. Immunologic Criteria Are Poor Predictors of Virologic Outcome: Implications for HIV Treatment Monitoring in Resource-Limited Settings. Clin Infect Dis. 2011 Dec;53(12):1283-1290.

Rossenkhan, R., Novitsky, V., Sebunya, T.K., Leidner, J., Hagan, J.E., Moyo, S., Smeaton, L., Lockman, S., Musonda, R., Ndung'u, T., Gaseitsiwe, S., Thior, I., Mmalane, M., Makhema, J., Essex, M., Shapiro, R. Infant Feeding Practices were not Associated with Breast Milk HIV-1 RNA Levels in a Randomized Clinical Trial in Botswana. AIDS Behav. 2011 Sep 7. [Epub ahead of print]

Wester, C.W., Koethe, J.R., Shepherd, B.E., Stinnette, S.E., Rebeiro, P.F., Kipp, A..M., Hong, H., Bussmann, H., Gaolathe, T., McGowan, C.C., Sterling, T.R., Marlink, R.G Non-AIDS Defining Events Among HIV-1 Infected Adults Receiving Combination Antiretroviral Therapy In Urban Settings in Sub-Saharan Africa and the United States. AIDS. May 12. (2011) [Epub ahead of print]

Write, J.K., Novitsky, V., Brockman, M.A., Brumme, Z.L., Brumme, C.J., Carlson, J.M., Heckerman, D., Wang, B., Losina, E., Leshwedi, M., van der Stok, M., Maphumulo, L., Mkhwanazi, N., Chonoc, F., Goulder, P.J.R., Essex, M., Walker, B.D., and Ndung'u, T. Influence of Gag-Protease-Mediated Replication Capacity on Disease Progression in Individuals Recently Infected with HIV-1 Subtype C. J of Virology. Feb 2. Epub ahead of print. (2011)

 

2010

Celum, C., Wald, A., Lingappa, J.R., Magaret, A.S., Wang, R.S., Mugo, N., Mujugira, A., Baeten, J.M., Mullins, J.I., Hughes, J.P., Bukusi, E.A., Cohen, C.R., Katabira, E., Ronald, A., Kiarie, J., Farquhar, C., Stewart, G.J., Makhema, J., Essex, M., Were, E., Fife, K.H., de Bruyn, G., Gray, G.E., McIntyre, J.A., Manongi, R., Kapiga, S., Coetzee, D., Allen, S., Inambao, M., Kayitenkore, K., Karita, E., Kanweka, W., Delany, S., Rees, H., Vwalika, B., Stevens, W., Campbell, M.S., Thomas, K.K., Coombs, R.W., Morrow, R., Whittington, W.L.H., McElrath, M.J., Barnes, L., Ridzon, R., and Corey, L., for the Partners in Prevention HSV/HIV Transmission Study Team. Acyclovir and Transmission of HIV-1 from Persons Infected with HIV-1 and HSV-2. N Engl J Med. 362:427 (2010).

Chen, J.Y., Ogwu, A.C., Svab, P., Lockman, S., Moffat, H.J., Gaolathe, T., Moilwa, S., Størdal, K., Dryden-Peterson, S., Moffat, C., Makhema, J., Essex, M., and Shapiro, R.L. Antiretroviral Treatment Initiation among HIV-Infected Pregnant Women with Low CD4+ Cell Counts in Gaborone, Botswana. J. Acquir. Immune Defic. Syndr. 54:102–6 (2010).

Chigwedere, P. and Essex, M. AIDS Denialism and Public Health Practice. AIDS Behav. 2010. Epub 8 January 2010.

Kebaabetswe, P., Ndase, P., Mujugira, A., Sekoto, T., Ntshimane, M., Owor, A., Makhema, J., Thior, I., and Essex, M. Perceptions of couple HIV counseling and testing in Botswana: A stakeholder analysis. Patient Educ. Couns. 79:120–3 (2010).

Lin, N.H., Negusse, D.M., Beroukhim, R., Giguel, F., Lockman, S., Essex, M., and Kuritzkes, D.R. The Design and Validation of a Novel Phenotypic Assay to Determine HIV-1 Coreceptor Usage of Clinical Isolates. J Virol Methods. 169:39–46 (2010).

Lingappa., J.R., Baeten, J.M., Wald, A., Hughes, J.P., Thomas, K.T., Mujugira, A., Mugo, N., Bukusi, E.A., Cohen, C.R., Katabira, E., Ronald, A., Kiarie, J., Farquhar, C., Steward, G.J., Makehma, J., Essex, M., Were, E., Fife, K.H., de Bruyen, G., Gray, G.E., McIntyre, J.A., Manongi, R., Kapiga, S., Coetzee, D., Allen, S., Inambao, M., Kayitenkore, K., Karita, E., Kanweka, W., Delany, S., Rees, H., Vwalika, B., Magaret, A.S., Wang, R.S., Kidoguchi, L., Barnes, L., Ridzon, R., Corey, L., and Celum, C. for the Partners in Prevention HSV/HIV Transmission Study Team. Daily aciclovir for HIV-1 disease progression in people dually infected with HIV-1 and herpes simplex virus type 2: a randomised placebo-controlled trial. The Lancet. 375: 824-833. (2010)

Lingappa, J.R., Hughes, J.P., Wang, R.S., Baeten, J.M., Celum, C., Gray, G.E., Stevens, W., Donnell, D., Campbell, M.S., Farquhar, C., Essex, M., Mullins, J.I., Coombs, R.W., Rees, H., Corey, L., and Wald, A. for the Partners in Prevention HSV/HIV Transmission Study Team. Estimating the Impact of Plasma HIV-1 RNA Reductions on Heterosexual HIV-1 Transmission Risk. PLoS One.5:e12598. (2010)

Lockman, S., Hughes, M.D., McIntyre, J., Zheng, Y., Chipato, T., Conradie, F., Sawe, F., Asmelash, A., Hosseinipour, M.C., Mohapi, L., Stringer, E., Mngqibisa, R., Siika, A., Atwine, D., Hakim, J., Shaffer, D., Kanyama, C., Wools-Kaloustian, K., Salata, R.A., Hogg, E., Alston-Smith, B., Walawander, A., Purcelle-Smith, E., Eshleman, S., Rooney, J., Rahim, S., Mellors, J.W., Schooley, R.T., Currier, J.S.; OCTANE A5208 Study Team. Antiretroviral therapies in women after single-dose nevirapine exposure. N Engl J Med. Oct 14; 363(16):1499-509. (2010).

MacLeod, I.J., Rowley, C.F., Essex, M., and Lockman, S. Minor Resistant Variants in Nevirapine-Exposed Infants May Predict Virologic Failure on Nevirapine-Containing ART. J. Clin. Virol. 48:162–7 (2010).

Novitsky, V., Wang, R., Bussmann, H., Lockman, S., Baum, M., Shapiro, R., Thior, I., Wester, C., Wester, C.W., Ogwu, A., Asmelash, A., Musonda, R., Campa, A., Moyo, S., van Widenfelt, E., Mine, M., Moffat, C., Mmalane, M., Makhema, J., Marlink, R., Gilbert, P., Seage, G.R. 3rd, DeGruttola, V., and Essex, M. HIV-1 Subtype C Infected Individuals Maintaining High Viral Load as Potential Targets for the “Test-and-Treat” Approach to Reduce HIV Transmission. PloS One. 5:e10148 (2010).

Novitsky, V., Wang, R., Lagakos, S., and Essex, M. HIV-1 Subtype C Phylodynamics in the Global Epidemic. Viruses. 2:33–54 (2010).

Novitsky, V., Wang, R., Margolin, L., Baca, J., Moyo, S., Musonda, R., and Essex, M. Dynamics and Timing of in Vivo Mutations at Gag Residue 242 during Primary HIV-1 Subtype C Infection. Virology. 403:37–46 (2010).

Plank, R.M., Makhema, J., Kebaabetswe, P., Hussein, F., Leseidi, C., Halperinm D., Bassil, B., Shapiro, R., Lockman, S. Acceptability of infant male circumcision as part of HIV prevention and male reporductive health efforts in Gaborone, Botswana, and surrounding areas. AIDS Behav. Oct;14(5):1198-202. (2010)

Rowley, C.F., Boutwell, C.L., Lee, E.J., MacLeod, I.J., Ribaudo, H.J., Essex, M, and Lockman, S. Ultrasensitive Detection of Minor Drug-Resistant Variants for HIV after Nevirapine Exposure Using Allele-Specific PCR: Clinical Significance. AIDS Res. Hum. Retroviruses. 26:293–300 (2010).

Shapiro, R., Hughes, M., Ogwu, A., Kitch, D., Lockman, S., Moffat, C., Makhema, J., Moyo, S., Thior, I., McIntosh, K., van Widenfelt, E., Leidner, J., Powis, K., Asmelash, A., Tumbare, E., Zwerski, S., Sharma, U., Handelsman, E., Mburu, K., Jayeoba, O., Moko, E., Souda, S., Lubega, E., Akhtar, M., Wester, C., Snowden, W., Martinez-Tristani, M., Mazhani, L., Essex, M. Antiretroviral Regimens in Pregnancy and Breast-Feeding in Botswana. N Engl J Med. 362:2282-2294. (2010).

Shapiro, R.L., Lockman, S. Mortality among HIV-exposed infants: the first and final frontier. Clin Infect Dis. Feb 1;50(3):445-7. (2010)

Teeravechyan, S., Essex, M., and Lee, T.H. Conserved Determinants of Enhanced CCR5 Binding in the Human Immunodeficiency Virus Subtype D Envelope Third Variable Loop. AIDS Res. Hum. Retroviruses. 26:481–8 (2010).

Wester, C.W., Thomas, A.M., Bussmann, H., Moyo, S., Makhema, J.M., Gaolathe, T.,Novitsky, V., Essex, M., DeGruttola, V., and Marlink, R.G. Non-nucleoside reverse transcriptase inhibitor outcomes among combination antiretroviral therapy-treated adults in Botswana. AIDS. Suppl 1:S27–36 (2010).

 

2009

Armstrong, K.L., Lee, TH, and Essex, M. Replicative Capacity Differences of Thymidine Analog Resistance Mutations in Subtype B and C Human Immunodeficiency Virus Type 1. J. Virol. 83: 4051-4059 (2009)

Boutwell, C.L., Rowley, C.F., and Essex, M. Reduced Viral Replication Capacity of HIV-1 Subtype C Caused by CTL Escape Mutations in HLA-B57 Epitopes of Capsid Protein. J. Virol. 83:2460–2468 (2009).

Bussmann, H., Wester, C.W., Thomas, A., Novitsky, V., Okezie, R., Muzenda, T., Gaolathe, T., Ndwapi, N., Mawoko, N., Widenfelt, E., Moyo, S., Musonda, R., Mine, M., Makhema, J., Moffat, H., Essex, M., DeGruttola, V., and Marlink, R.G. Response to Zidovudine/Didanosine-Containing Combination Antiretroviral Therapy Among HIV-1 Subtype C-Infected Adults in Botswana: Two-Year Outcomes from a Randomized Clinical Trial. J Acquir Immune Defic Syndr. 51:37–46 (2009).

Chen, J.Y., Ogwu, A.C., Svab, P., Lockman, S., Moffat, H.J., Gaolathe, T., Moilwa, S., Størdal, K., Dryden-Peterson, S., Moffat, C., Makhema, J., Essex, M., and Shapiro, R.L. Antiretroviral Treatment Initiation among HIV-Infected Pregnant Women with Low CD4+ Cell Counts in Gaborone, Botswana. J Acquir Immune Defic Syndr. Epub 27 October 2009.

Doualla-Bell, F., Gaolathe, T., Avalos, A., Cloutier, S., Ndwapi, N., Holcroft, C., Moffat., H., Dickinson, D., Essex, M., Wainberg, M.A., Mine, M. Five-year followu up of genotypic resistance pattersn in HIV-1 subtupe C infected patients in Botwswana after failure of thymidine analogue-based regimens. J. of International AIDS Society. 12:25. (2009)

Lingappa, J.R., Kahle E., Mugo, N., Mujugira, A., Magaret, A., Baeten, J., Bukusi, E.A., Cohen, C.R., Katabira, E., Ronald, A., Kiarie, J., Farquhar, C., Stewart, G.J., Makhema, J., Essex, M., Were E., Fife K., deBruyn, G., Gray, G., McIntyre, J., Manongi, R., Kapiga, S., Coetzee, D., Allen, S., Inambao, M., Kayitenkore, K., Karita, E., Kanweka, W., Delany, S., Rees, H., Vwalika, B., Coombs, R.W., Morrow, R., Whittington, W., Corey, L., Wald, A., and Celum, C., for the Partners HSV-2/HIV-1 Transmission Study Team. Characteristics of HIV-1 Discordant Couples Enrolled in a Trial of HSV-2 Suppression to Reduce HIV-1 Transmission: The Partners Study. PLoS ONE. 4:e5272 (2009).

Lockman, S., Creek, T. Acute maternal HIV infection during pregnancy and breast-feeding: substantial risk to infants. J Infect Dis. Sep 1;200(5):667-9. (2009)

Novitsky, V., Lagakos, S., Herzig, M., Bonney, C., Kebaabetswe, L, Rossenkhan, R., Nkwe, D., Margolin, L., Musonda, R., Moyo, S., Woldegabriel, E., van Widenfelt, E., Makhema, J., and Essex, M. Evolution of Proviral gp120 over the First Year of HIV-1 Subtype C Infection. Virology. 383:47–59 (2009).

Novitsky, V., Wang, R., Margolin, L., Baca, J., Kebaabetswe, L., Rossenkhan, R., Bonney, C., Herzig, M., Nkwe, D., Moyo, S., Musonda, R., Woldegabriel, E., van Widenfelt, E., Makhema, J., Lagakos, S., and Essex, M. Timing Constraints of in Vivo Gag Mutations during Primary HIV-1 Subtype C Infection. PLoS One. 4:e7727 (2009).

Novitsky, V., Wang, R., Kebaabetswe, L., Greenwald, J., Rossenkhan, R., Moyo, S., Musonda, R., Woldegabriel, E., Lagakos, S., and Essex, M. Better Control of Early Viral Replication Is Associated with Slower Rate of Elicited Antiviral Antibodies in the Detuned EIA during Primary HIV-1C Infection. J. Acquir. Immune Defic. Syndr. 52:265–272 (2009). .

Novitsky, V., Woldegabriel, E., Kebaabetswe, L., Rossenkhan, R., Mlotshwa, B., Bonney, C., Herzig, M., Finucane, M., Musonda, R., Moyo, S., Wester, C., van Widenfelt, E., Makhema, J., Lagakos, S., and Essex, M. Viral Load and CD4+ T Cell Dynamics in Primary HIV-1 Subtype C Infection. J. Acquir. Immune Defic. Syndr. 50:65–76 (2009).

Mine, M., Bedi, K., Maruta, T., Madziva, D., Tau, M., Zana, T., Gaolathe, T., Moyo, S., Seipone, K., Ndwapi, N., Essex, M., and Marlink, R. Quantitation of Human Immunodeficiency Virus Type 1 Viral Load in Plasma Using Reverse Transcriptase Activity Assay at a District Hospital Laboratory in Botswana: A Decentralization Pilot Study. J. Virol. Methods. 159:93–97 (2009).

Rossenkhan, R., Ndung’u, T., Sebunya, T., Hagan, J., Shapiro, R., Novitsky, V., Moyo, S.M., Thior, I., Lockman, S., Mitchell, R., Kim, S., Musonda, R., van Widenfelt, E., Makhema, J., and Essex, M. Temporal Reduction of HIV Type 1 Viral Load in Breast Milk by Single-Dose Nevirapine during Prevention of MTCT. AIDS Res. Hum. Retroviruses. 25:1261–4 (2009).

Shapiro, R.L., Smeaton, L., Lockman, S., Thior, I., Rossenkahn, R., Wester, C., Stevens, L., Moffat, C., Arimi, P., Ndase, P., Asmelash, A., Leidner, J., Novitsky, V., Makhema, J., and Essex, M. Risk Factors for Early and Late Transmission of HIV via Breast-Feeding among Infants Born to HIV-Infected Women in a Randomized Clinical Trial in Botswana. J. Infect. Dis. 199:414–418 (2009).

Shipton, L.K., Wester, C.W., Stock, S., Ndwapi, N., Gaolathe, T., Thior, I., Avalos, A., Moffat, H.J., Mboya J.J., Widenfelt, E., Essex, M., Hughes, M.D., and Shapiro, R.L. Safety and Efficacy of Nevirapine and Efavarinz-Based Antiretroviral Treatment in Adults Treated for TB-HIV Co-Infection in Botswana. Int. J. Tuberc. Lung Dis. 13:360–366 (2009).

Wester, C.W., Bussmann, H., Koethe, J., Moffat, C., Vermund, S., Essex, M., and Marlink, R.G. Adult Combination Antiretroviral Therapy in Sub-Saharan Africa: Lessons from Botswana and Future Challenges. HIV Ther. 3:501–526 (2009).

 

2008

Assoumou, L., Brun-Vezinet, F., Cozzi-Lepri, A., Kuritzkes, D., Phillips, A., Zolopa, A., Degruttola, V., Miller, V., Costagliola, D. Initiatives for developing and comparing genotype interpretation systems: external validation of existing systems for didanosine against virological response. J. Infect. Dis. Aug 15; 198(4): 470-80 (2008)

Bae, W.H., Wester, C., Shapiro, R.L., Lockman, S., Onyait, K., Thior, I., and Essex, M. Hematologic and Hepatic Toxicities Associated with Antenatal and Postnatal Exposures to Maternal HAART in Infants in Botswana. AIDS. 22:1633–1640 (2008).

Bangsberg, DR. Preventing HIV antiretroviral resistance through better monitoring of treatment adherence. J. Infect. Dis. May 15; 197 Suppl 3: S272-8 (2008)

Bangsberg, DR. A paradigm shift to prevent HIV drug resistance. PLoS Med. May 20; 5(5): e111 (2008)

Bangsberg, DR. The Achilles' heel of HIV treatment in resource-limited settings. JAIDS. Feb 1; 47(2): 266-7 (2008)

Bussmann, C., Rotz, P., Ndwapi, N., Baxter, D., Bussmann, Hi., Wester, W.C., Ncube, P., Avalos, A., Mine, M., Mabe, E., Burns, P.J., Cardiello, P., Makehma, J., Marlink, R. Strengthening Healthcard Capacity Through a Responsive, Country-Specific, Training Standard: The KITSO AIDS Training Program's Support of Botswana's National Antiretroviral Therapy Rollout. The Open AIDS Journal, 2:8-20 (2008)

Bussmann, H., Wester, C.W., Ndwapi, N., Grundmann, N., Gaolathe, T., Puvimanasinghe, J., Avalos, A., Mine, M., Seipone, K., Essex, M., deGruttola, V., and Marlink, R.G. Five-Year Outcomes of Initial Patients Treated in Botswana’s National Antiretroviral Treatment Program. AIDS. 22:2303–2311 (2008).

Chigwedere, P., Seage, G.R. III, Lee, T.H., and Essex, M. Efficacy of Antiretroviral Drugs in Reducing Mother to Child Transmission of HIV in Africa: A Meta-Analysis of Published Clinical Trials. AIDS Res. Hum. Retroviruses. 24(6): 827-37 (2008).

Chigwedere, P., Seage, G.R., III, Gruskin, S., Lee, T.-H., and Essex, M. Estimating the Lost Benefits of Antiretroviral Drug Use in South Africa. J. Acquir. Immune Defic. Syndr. 49:410–415 (2008).

Earls, F., Raviola, GJ., Carlson, M. Promoting child and adolescent mental health in the context of the HIV/AIDS pandemic with a focus on sub-Saharan Africa. J-Child-Psychol-Psychiatry. Mar; 49(3): 295-312 (2008)

Essex, M., and Lu, Y. HIV/AIDS: Lessons from a New Disease Pandemic. In: Emerging Infections in Asia. Lu, Y., Essex, M., and Roberts, B., eds. New York: Springer, pp. 133-142 (2008).

Fisher, JC., Cook, PA., Sam, NE., Kapiga, SH. Patterns of alcohol use, problem drinking, and HIV infection among high-risk African women. Sex. Transm. Dis. Jun; 35(6): 537-44 (2008)

Frosythe S, Bertozzi S, Moatti JP, Marlink R, Luchini S, Kazatchkine M. I. Infoming scale-up and resource allocation: the use of economic analysis. II. Universal Access to HIV Treatment in Developing Countries: Going Beyond the Misinterpretations of the “Cost-effectiveness” Algorithm. III. The Economic Impact of HIV/AIDS on households and economies. AIDS, Volume 22 Suppl 1:S5-S6, S59-S66, S87-S88. July 2008.

Gruskin, S., Tarantola, D. Universal Access to HIV prevention, treatment and care: assessing the inclusion of human rights in international and national strategic plans. AIDS. Aug; 22 Suppl 2: S123-32 (2008)

Gruskin, S., Firestone, R., Maccarthy, S., Ferguson, L. HIV and pregnancy intentions: do services adequately respond to women's needs? Am. J. Public Health. Oct; 98(10): 1746-50 (2008)

Hendrickson, SL., Jacobson, LP., Nelson, GW., Phair, JP., Lautenberger, J., Johnson, RC., Kingsley, L., Margolick, JB., Detels, R., Goedert, JJ., O'Brien, SJ. Host genetic influences on highly active antiretroviral therapy efficacy and AIDS-free survival. JAIDS. Jul 1; 48(3): 263-71 (2008)

Hughes, MD., Ribaudo, HR. The search for data on when to start treatment for HIV infection. J. Infect. Dis. Apr 15; 197(8): 1084-6 (2008)

Hutcheson, HB., Lautenberger, JA., Nelson, GW., Pontius, JU., Kessing, BD., Winkler, CA., Smith, MW., Johnson, R., Stephens, R., Phair, J., Goedert, JJ., Donfield, S., O'Brien, SJ. Detecting AIDS restriction genes: from candidate genes to genome-wide association discovery. Vaccine. Jun 6; 26(24): 2951-65 (2008)

Kamo, N., Carlson, M., Brennan, RT., Earls, F. Young citizens as health agents: use of drama in promoting community efficacy for HIV/AIDS. Am. J. Public Health. Feb; 98(2): 201-4 (2008)

Kupka, R., Mugusi, F., Aboud, S., Msamanga, GI., Finkelstein, JL., Spiegelman, D., Fawzi, WW. Randomized, double-blind, placebo-controlled trial of selenium supplements among HIV-infected pregnant women in Tanzania: effects on maternal and child outcomes. Am. J. Clin. Nutr. Jun; 87(6): 1802-8 (2008)

Kuritzkes, DR. HIV-1 subtype as a determinant of disease progression. J. Infect. Dis. Mar 1; 197(5): 638-9 (2008)

Kuritzkes, DR., Lalama, CM., Ribaudo, HJ., Marcial, M., Meyer, WA, 3rd; Shikuma, C., Johnson,V A., Fiscus, SA., D'Aquila, RT., Schackman, BR., Acosta, EP., Gulick, RM. Preexisting resistance to nonnucleoside reverse-transcriptase inhibitors predicts virologic failure of an efavirenz-based regimen in treatment-naive HIV-1-infected subjects. J. Infect. Dis. Mar 15; 197(6): 867-70 (2008)

Lagakos, SW., Gable, AR. Challenges to HIV prevention--seeking effective measures in the absence of a vaccine. N. Engl. J. Med. Apr 10; 358(15): 1543-5 (2008)

Marconi, V., Bonhoeffer, S., Paredes, R., Lu, J., Hoh, R., Martin, JN., Deeks, SG., Kuritzkes, DR. Viral dynamics and in vivo fitness of HIV-1 in the presence and absence of enfuvirtide.JAIDS. Aug 15; 48(5): 572-6 (2008)

Marconi, VC., Sunpath, H., Lu, Z., Gordon, M., Koranteng-Apeagyei, K., Hampton, J., Carpenter, S., Giddy, J., Ross, D., Holst, H., Losina, E., Walker, BD., Kuritzkes, DR. Prevalence of HIV-1 drug resistance after failure of a first highly active antiretroviral therapy regimen in KwaZulu Natal, South Africa. Clin. Infect. Dis. May 15; 46(10): 1589-97 (2008)

Marlink, R., Forsythe, S., Bertozzi, SM., Muirhead, D., Holmes, M., Sturchio, J. Re: This special issue of AIDS--a mix of recent economic analyses and commentary on how best to distill economic insights to improve HIV/AIDS policies and programmes. AIDS. Jul; 22 Suppl 1: S1-4
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Marlink,-R; Forsythe,-S; Bertozzi,-S-M; Muirhead,-D; Holmes,-M; Sturchio,-J. Informing scale-up and resource allocation: the use of economic analysis. AIDS. Jul; 22 Suppl 1: S5-6 (2008)

Marlink,-R; Forsythe,-S; Bertozzi,-S-M; Muirhead,-D; Holmes,-M; Sturchio,-J. The economic impacts of HIV/AIDS on households and economies. AIDS. Jul; 22 Suppl 1: S87-8 (2008)

Martinez, P., Andia, I., Emenyonu, N., Hahn, J A., Hauff, E., Pepper, L., Bangsberg, DR. Alcohol use, depressive symptoms and the receipt of antiretroviral therapy in southwest Uganda. AIDS-Behav. Jul; 12(4): 605-12 (2008)

Moatti, JP., Marlink, R., Luchini, S., Kazatchkine, M. Universal access to HIV treatment in developing countries: going beyond the misinterpretations of the 'cost-effectiveness' algorithm. AIDS. Jul; 22 Suppl 1: S59-66 (2008)

Moatti, J-P, Marlink, R., Luchini, S., Kazatchkine, M., Universal Access to HIV Treatnent in Developing Countries: Going Beyond the Misinterpretations of the "Cost-effectiveness" Algorithm. AIDS, 22:S59-S6 (2008).

Msisha, WM., Kapiga, S H., Earls, F J. Subramanian,-S-V. Place matters: multilevel investigation of HIV distribution in Tanzania. AIDS. Mar 30; 22(6): 741-8 (2008)

Novitsky, V., Woldegabriel, E., Wester, C., McDonald, E., Rossenkhan, R., Ketunuti, M., Makhema, J., Seage, G.R, III, and Essex, M. Identification of Primary HIV-1C Infection in Botswana. AIDS Care. 20(7): 806-11 (2008).

Ojesina, AI., Chaplin, B., Sankale, JL., Murphy, R., Idigbe, E., Adewole, I., Ekong, E., Idoko, J., Kanki, PJ. Interplay of Reverse Transcriptase Inhibitor Therapy and Gag p6 Diversity in HIV Type 1 Subtype G and CRF02_AG. AIDS-Res-Hum-Retroviruses. Sep; 24(9): 1167-74 (2008)

Parienti, JJ., Das-Douglas, M., Massari, V., Guzman, D., Deeks, SG., Verdon, R., Bangsberg, DR. Not all missed doses are the same: sustained NNRTI treatment interruptions predict HIV rebound at low-to-moderate adherence levels. PLoS ONE. 3(7): e2783 (2008)

Patel, K., Hernan, MA., Williams, PL., Seeger, JD., McIntosh, K., Van-Dyke, RB., Seage, GR, 3rd., Long-term effectiveness of highly active antiretroviral therapy on the survival of children and adolescents with HIV infection: a 10-year follow-up study. Clin. Infect. Dis. Feb 15; 46(4): 507-15 (2008)

Patel, K., Hernan, MA., Williams, PL., Seeger, JD., McIntosh, K., Dyke, RB., Seage, GR, 3rd. Long-term effects of highly active antiretroviral therapy on CD4+ cell evolution among children and adolescents infected with HIV: 5 years and counting. Clin. Infect. Dis. Jun 1; 46(11): 1751-60 (2008)

Phuphuakrat A, Kraiwong R, Boonarkart C, Lauhakirti D, Lee TH, Auewarakul P. Double-stranded RNA adenosine deaminases enhance expression of human immunodeficiency virus type 1 proteins. J Virol. Nov;82(21):10864-72. (2008)

Rowley, C.F., Boutwell, C.L., Lockman, S., and Essex, M. Improvement in Allele-Specific PCR Assay with the Use of Polymorphism-Specific Primers for the Analysis of Minor Variant Drug Resistance in HIV-1 subtype C. J. Virol. Methods.149:69–75 (2008).

Schumi, J., Degruttola, V. Resampling-based analyses of the effects of combinations of HIV genetic mutations on drug susceptibility. Stat. Med. Oct 15; 27(23): 4740-57 (2008)

Tarantola, D., Gruskin, S. Pragmatic pathways to universal access: leadership, equity, accountability and partnerships in HIV prevention and care. AIDS. Aug; 22 Suppl 2: S1-2 (2008)

Teeravechyan, S., Suphaphiphat, P., Essex, M., and Lee, T.H. Relative Concordance of Human Immunodeficiency Virus Oligomeric and Monomeric Envelope in CCR 5 Coreceptor Usage. Virology. 340:443-450 (2008).

Toure, S., Kouadio, B., Seyler, C.,Traore, M., Dakoury-Dogbo, N., Duvignac, J., Diakite, N., Karcher, S. Grundmann, C., Marlink, R., Dabis, F., Anglaret, X. Rapid scaling-up of antiretroviral therapy in 10,000 adults in Cote d'Ivoire: 2-year outcomes and determinants. AIDS. Apr 23; 22(7): 873-82 (2008)

Tsibris, AM., Sagar, M., Gulick, RM., Su, Z., Hughes, M., Greaves, W., Subramanian,M., Flexner, C., Giguel, F., Leopold, KE., Coakley, E., Kuritzkes, DR. In vivo emergence of vicriviroc resistance in a human immunodeficiency virus type 1 subtype C-infected subject. J. Virol. Aug; 82(16): 8210-4 (2008)

Ulenga, NK., Sarr, AD., Thakore-Meloni, S., Sankale, J-L., Eisen, G., Kanki, PJ. Relationship between human immunodeficiency type 1 infection and expression of human APOBEC3G and APOBEC3F. J. Infect. Dis. Aug 15; 198(4): 486-92 (2008)

Ulenga, NK., Sarr, AD., Hamel, D., Sankale, JL., Mboup, S., Kanki, PJ. The Level of APOBEC3G (hA3G)-Related G-to-A Mutations Does Not Correlate with Viral Load in HIV Type 1-Infected Individuals. AIDS Res. Hum. Retroviruses. Oct; 24(10): 1285-90 (2008)

Villamor, E., Mugusi, F., Urassa, W., Bosch, RJ., Saathoff, E., Matsumoto, K., Meydani, SN., Fawzi, WW. A trial of the effect of micronutrient supplementation on treatment outcome, T cell counts, morbidity, and mortality in adults with pulmonary tuberculosis. J. Infect. Dis. Jun 1; 197(11): 1499-505 (2008)

Williams, PL., Van-Dyke, R., Eagle, M., Smith, D., Vincent, C., Ciupak, G., Oleske, J., Seage, GR, 3rd. Association of site-specific and participant-specific factors with retention of children in a long-term pediatric HIV cohort study. Am. J. Epidemiol. Jun 1; 167(11): 1375-86 (2008)

Yang, Y., Degruttola, V. Resampling-based multiple testing methods with covariate adjustment: application to investigation of antiretroviral drug susceptibility. Biometrics. Jun; 64(2): 329-36 (2008)

Zhang, P., Lagakos, SW. Analysis of time to a silent event whose occurrence is monitored with error, with application to mother-to-child HIV transmission. Stat. Med. Oct 15; 27(23): 4637-46 (2008)

 


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