“Over the past 10 years, the work carried out at the Botswana-Harvard Partnership, known to many of us as BHP, has provided scientific insight that encourages and inspires our battle.”
- Festus Mogae
Former President of Botswana: 1998–2008
As the number of AIDS cases continues to escalate worldwide, HAI has directed its research efforts toward developing prevention and treatment strategies to stem the epidemic within Africa and other resource-scarce settings. Recently, HAI researchers have found that the HIV subtype that exists within Africa—HIV-1C—mutates faster and displays more diversity than any other subtype in the world. As a result, in Africa, researchers are testing the efficacy of an HIV vaccine and new genetic delivery systems; conducting studies on antiretroviral treatment, treatment adherence and drug resistance; and developing interventions to prevent mother-to-child HIV transmission.
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| A volunteer at the Molepolole site |
The Botswana-Harvard HIV Reference Laboratory, the largest HIV/AIDS laboratory in Africa, houses clinical, epidemiologic and laboratory research for the prevention of mother-to-child transmission (PMTCT) of HIV and the genomic analysis of HIV-1C, the viral sub-type predominant in southern Africa. Research is also conducted on resistance and adherence to anti-retroviral drugs, Herpes and HIV, prevention of HIV, and the cost-effectiveness of various interventions for prevention and treatment. The Reference Laboratory serves as a training facility, building and expanding the professional infrastructure in Botswana through training the nation’s future researchers and laboratory technicians.
As well as conducting clinical, epidemiologic and laboratory-based research, the Botswana-Harvard Partnership (BHP) is home to the KITSO AIDS Training Program which provides health care professionals in Botswana with the opportunity to enrich their HIV and AIDS clinical knowledge and practice.
For more information visit bhp.org.bw.
2013
Powis KM, McElrath TF, Hughes MD, Ogwu A, Souda S, Datwyler SA, von Widenfelt E, Moyo S, Nádas M, Makhema J, Machakaire E, Lockman S, Essex M, Shapiro RL. High Viral Load and Elevated Angiogenic Markers Associated with Increased Risk of Preeclampsia among Women Initiating Highly Active Antiretroviral Therapy (HAART) in Pregnancy in the Mma Bana Study, Botswana. J Acquir Immune Defic Syndr. 2013 Jan 22
Plank RM, Ndubuka NO, Wirth KE, Mwambona JT, Kebaabetswe P, Bassil B, Lesetedi C, Hussein FM, Magetse J, Nkgau M, Makhema J, Mmalane M, Creek T,Powis KM, Shapiro R, Lockman S. A Randomized Trial of Mogen Clamp versus Plastibell for Neonatal Male Circumcision in Botswana. J Acquir Immune Defic Syndr. 2013 Jan 10
2012
Thio CL, Smeaton L, Saulynas M, Hwang H, Saravanan S, Kulkarni S, Hakim J, Nyirenda M, Iqbal HS, Lalloo UG, Mehta AS, Hollabaugh K, Campbell TB,Lockman S, Currier JS. Characterization of HIV-HBV co-infection in a multi-national HIV-infected cohort. AIDS. 2012 Oct 22
Wester, C.W., Stitelman, O.M., Degruttola, V., Bussmann, H., Marlink, R.G., van der Laan, M.J. Effect Modification by Sex and Baseline CD4+ Cell Count Among Adults Receiving Combination Antiretroviral Therapy in Botswana: Results from a Clinical Trial. AIDS Res Hum Retroviruses. 2012 Feb 6. [Epub ahead of print]
Dong, B.J., Zheng, Y., Hughes, M.D., Frymoyer, A., Verotta, D., Lizak, P., Sawe, F., Currier, J.S., Lockman, S., Aweeka, F.T.; for the AIDS Clinical Trials Group Study 5208 Team. Nevirapine (NVP) pharmacokinetics (PK) and risk of rash and hepatitis among HIV-infected Sub-Saharan African Women. AIDS. 2012 Feb 1. [Epub ahead of print]
Laeyendecker, O., Brookmeyer, R., Mullis, C., Donnell, D., Lingappa, J., Celum, C., Baeten, J.M., Campbell, M.S., Essex, M., de Bruyn, G., Farquhar, C., Quinn, T.C., Eshleman, S. Specificity of four laboratory approaches for cross-sectional HIV incidence determination: Analysis of samples from adults with known non-recent HIV infection from five African countries. AIDS Res Hum Retroviruses. 2012 Jan 29. [Epub ahead of print]
Novitsky, V., Essex, M. Using HIV viral load to guide treatment-for-prevention interventions. Curr Opin HIV AIDS. 2012 Jan 16. [Epub ahead of print]
2011
Baeten, J.M., Lingappa, J., Beck., I., Freukel, L., Pepper, G., Wald, A., Fife, K., Were, E., Mugo, N., Sanchez, J., Essex, M., Makhema, J., Kiare, J., Farquhar, C., Corey, L., and Celum, C. Herpes Simplex Virus Type 2 Suppressive Therapy with Acyclovir or Valacyclovir Does Not Select for Specific HIV-1 Resistance in HIV 1/HSV-2 Dually Infected Persons. J. Infect. Dis. 203:117–21 (2011).
Bussmann, H., de la Hoz Gomez, F., Roels, T.H., Wester, C.W., Bodika, S.M., Moyo, S., Taffa, N., Anderson, M.G., Mine, M., Bile, E.C., Yang, C., Mphoyakgosi, K., Lehotzky, E.A., Mlotshwa, B., Mmelesi, M., Seipone, K., Makhema, M.J., Marlink, R.G., Novitsky, V., Essex, M. Prevalence of transmitted HIV drug resistance in Botswana: lessons learned from the HIVDR-Threshold Survey conducted among women presenting for routine antenatal care as part of the 2007 national sentinel survey. AIDS ResHum Retroviruses. Apr;27(4):365-72. (2011)
Cohen, M.S., Chen, Y.Q., McCauley, M., Gamble, T., Hosseinipour, M.C., Kumarasamy, N., Hakim, J.G., Kumwenda, J., Grinsztejn, B., Pilotto, J.H., Godbole, S.V., Mehendale, S., Chariyalertsak, S., Santos, B.R., Mayer, K.H., Hoffman, I.F., Eshleman, S.H., Piwowar-Manning, E., Wang, L., Makhema, J., Mills, L.A., de Bruyn, G., Sanne, I., Eron, J., Gallant, J., Havlir, D., Swindells, S., Ribaudo, H., Elharrar, V., Burns, D., Taha, T.E., Nielsen-Saines, K., Celentano, D., Essex, M., Fleming, T.R.; the HPTN 052 Study Team. Prevention of HIV-1 Infection with Early Antiretroviral Therapy. N Engl J Med. 2011 Jul 18. [Epub ahead of print]
Dryden-Peterson, S., Jayeoba, O., Hughes, M.D., Jibril, H., Keapoletswe, K., Tlale, J., Modise, T.A., Asmelash, A., Moyo, S., van Widenfel,t E., Makhema, J., Essex, M., Shapiro, R.L., Lockman, S. Highly Active Antiretroviral Therapy versus Zidovudine for Prevention of Mother-to-Child Transmission in a Programmatic Setting, Botswana. J Acquir Immune Defic Syndr. 2011 Jul 22. [Epub ahead of print]
Dryden-Peterson, S., Shapiro, R.L., Hughes, M.D., Powis, K., Ogwu, A., Moffat, C., Moyo, S., Makhema, J., Essex, M., Lockman, S. Increased Risk of Severe Infant Anemia Following Exposure to Maternal HAART, Botswana. JAIDS. Jan 25. Epub ahead of print. (2011)
Firnhaber, C., Evans, D., Friedman-Khalili, R., Willliams, S., Michelow, P., Matlhagela, K., Wester, C., Grinsztejn, B., Lockman, S. Seroprevalence of HPV vaccine types 6, 11, 16 and 18 in HIV-infected women from South Africa, Brazil and Botswana. J Clin Virol. 2011 Sep 9. [Epub ahead of print]
Lin, N.H., Smeaton, L.M., Giguel, F., Novitsky, V., Moyo, S., Mitchell, R.M., Makhema, J., Essex, M., Lockman, S., and Kuritzkes, D.R. Prevalence and clinical associations of CXCR4-using HIV-1 among treatment-naive subtype C-infected women in Botswana. JAIDS. Feb 21. Epub ahead of print. (2011)
Matthews, L.T., Ribaudo, H.J., Parekh, N.K., Chen, J.Y., Binda, K., Ogwu, A., Makhema, J., Souda, S., Lockman, S., Essex, M., Shapiro, R.L. Birth weight for gestational age norms for a large cohort of infants born to HIV-negative women in Botswana compared with norms for U.S-born black infants. BMC Pediatr. 2011 Dec 16;11(1):115. [Epub ahead of print]
Novitsky, V., Ndung'u, T., Wang, R., Bussmann, H., Chonco, F., Makhema, J., De Gruttola, V., Walker, B.D., Essex, M. Extended high viremics: a substantial fraction of individuals maintain high plasma viral RNA levels after acute HIV-1 subtype C infection. AIDS. Apr 18. (2011). [Epub ahead of print].
Novitsky, V., Wang, R., Margolin, L., Baca, J., Rossenkhan, R., Moyo, S., van Widenfelt, E., and Essex, M. Transmission of Single and Multiple Viral Variants in Primary HIV-1 Subtype C Infection. PLoS One. 6:e16714 (2011).
Parekh, N., Ribaudo, H., Souda, S., Chen, J., Mmalane, M., Powis, K., Essex, M., Makhema, J., Shapiro, R.L. Risk factors for very preterm delivery and delivery of very-small-for-gestational-age infants among HIV-exposed and HIV-unexposed infants in Botswana. Int J Gynaecol Obstet. 2011 Jul 16. [Epub ahead of print]
Powis, K.M., Kitch, D., Ogwu, A., Hughes, M.D., Lockman, S., Leidner, J., van Widenfelt, E., Moffat, C., Moyo, S., Makhema, J., Essex, M., Shapiro, R.L. Increased Risk of Preterm Delivery Among HIV-Infected Women Randomized to Protease Versus Nucleoside Reverse Transcriptase Inhibitor-Based HAART During Pregnancy. J Infect Dis. 2011 Aug;204(4):506-14.
Powis, K.M., Smeaton, L., Ogwu, A., Lockman, S. Dryden-Peterson, S., van Widenfelt, E., Leidner, J., Makhema, J., Essex, M., and Shapiro, R.L. Effects of in utero antiretroviral exposure on longitudinal growth of HIV-exposed uninfected infants in Botswana. JAIDS. 1:56(2):131–8. (2011)
Rossenkhan, R., Novitsky, V., Sebunya, T.K., Leidner, J., Hagan, J.E., Moyo, S., Smeaton, L., Lockman, S., Musonda, R., Ndung'u, T., Gaseitsiwe, S., Thior, I., Mmalane, M., Makhema, J., Essex, M., Shapiro, R. Infant Feeding Practices were not Associated with Breast Milk HIV-1 RNA Levels in a Randomized Clinical Trial in Botswana. AIDS Behav. 2011 Sep 7. [Epub ahead of print]
Wester, C.W., Koethe, J.R., Shepherd, B.E., Stinnette, S.E., Rebeiro, P.F., Kipp, A..M., Hong, H., Bussmann, H., Gaolathe, T., McGowan, C.C., Sterling, T.R., Marlink, R.G Non-AIDS Defining Events Among HIV-1 Infected Adults Receiving Combination Antiretroviral Therapy In Urban Settings in Sub-Saharan Africa and the United States. AIDS. May 12. (2011) [Epub ahead of print]
2010
Celum, C., Wald, A., Lingappa, J.R., Magaret, A.S., Wang, R.S., Mugo, N., Mujugira, A., Baeten, J.M., Mullins, J.I., Hughes, J.P., Bukusi, E.A., Cohen, C.R., Katabira, E., Ronald, A., Kiarie, J., Farquhar, C., Stewart, G.J., Makhema, J., Essex, M., Were, E., Fife, K.H., de Bruyn, G., Gray, G.E., McIntyre, J.A., Manongi, R., Kapiga, S., Coetzee, D., Allen, S., Inambao, M., Kayitenkore, K., Karita, E., Kanweka, W., Delany, S., Rees, H., Vwalika, B., Stevens, W., Campbell, M.S., Thomas, K.K., Coombs, R.W., Morrow, R., Whittington, W.L.H., McElrath, M.J., Barnes, L., Ridzon, R., and Corey, L., for the Partners in Prevention HSV/HIV Transmission Study Team. Acyclovir and Transmission of HIV-1 from Persons Infected with HIV-1 and HSV-2. N Engl J Med. 362:427 (2010).
Chen, J.Y., Ogwu, A.C., Svab, P., Lockman, S., Moffat, H.J., Gaolathe, T., Moilwa, S., Størdal, K., Dryden-Peterson, S., Moffat, C., Makhema, J., Essex, M., and Shapiro, R.L. Antiretroviral Treatment Initiation among HIV-Infected Pregnant Women with Low CD4+ Cell Counts in Gaborone, Botswana. J. Acquir. Immune Defic. Syndr. 54:102–6 (2010).
Do NT, Phiri K, Bussmann H, Gaolathe T, Marlink RG, Wester CW. Psychosocial factors affecting medication adherence among HIV-1 infected adults receiving combination antiretroviral therapy (cART) in Botswana. AIDS Res Hum Retroviruses. 2010 Jun;26(6):685-91.
Kebaabetswe, P., Ndase, P., Mujugira, A., Sekoto, T., Ntshimane, M., Owor, A., Makhema, J., Thior, I., and Essex, M. Perceptions of couple HIV counseling and testing in Botswana: A stakeholder analysis. Patient Educ. Couns. 79:120–3 (2010).
Lingappa., J.R., Baeten, J.M., Wald, A., Hughes, J.P., Thomas, K.T., Mujugira, A., Mugo, N., Bukusi, E.A., Cohen, C.R., Katabira, E., Ronald, A., Kiarie, J., Farquhar, C., Steward, G.J., Makehma, J., Essex, M., Were, E., Fife, K.H., de Bruyen, G., Gray, G.E., McIntyre, J.A., Manongi, R., Kapiga, S., Coetzee, D., Allen, S., Inambao, M., Kayitenkore, K., Karita, E., Kanweka, W., Delany, S., Rees, H., Vwalika, B., Magaret, A.S., Wang, R.S., Kidoguchi, L., Barnes, L., Ridzon, R., Corey, L., and Celum, C. for the Partners in Prevention HSV/HIV Transmission Study Team. Daily aciclovir for HIV-1 disease progression in people dually infected with HIV-1 and herpes simplex virus type 2: a randomised placebo-controlled trial. The Lancet. 375: 824-833. (2010)
Lingappa, J.R., Hughes, J.P., Wang, R.S., Baeten, J.M., Celum, C., Gray, G.E., Stevens, W., Donnell, D., Campbell, M.S., Farquhar, C., Essex, M., Mullins, J.I., Coombs, R.W., Rees, H., Corey, L., and Wald, A. for the Partners in Prevention HSV/HIV Transmission Study Team. Estimating the Impact of Plasma HIV-1 RNA Reductions on Heterosexual HIV-1 Transmission Risk. PLoS One.5:e12598. (2010)
Lockman, S., Hughes, M.D., McIntyre, J., Zheng, Y., Chipato, T., Conradie, F., Sawe, F., Asmelash, A., Hosseinipour, M.C., Mohapi, L., Stringer, E., Mngqibisa, R., Siika, A., Atwine, D., Hakim, J., Shaffer, D., Kanyama, C., Wools-Kaloustian, K., Salata, R.A., Hogg, E., Alston-Smith, B., Walawander, A., Purcelle-Smith, E., Eshleman, S., Rooney, J., Rahim, S., Mellors, J.W., Schooley, R.T., Currier, J.S.; OCTANE A5208 Study Team. Antiretroviral therapies in women after single-dose nevirapine exposure. N Engl J Med. Oct 14; 363(16):1499-509. (2010).
MacLeod, I.J., Rowley, C.F., Essex, M., and Lockman, S. Minor Resistant Variants in Nevirapine-Exposed Infants May Predict Virologic Failure on Nevirapine-Containing ART. J. Clin. Virol. 48:162–7 (2010).
Novitsky, V., Wang, R., Bussmann, H., Lockman, S., Baum, M., Shapiro, R., Thior, I., Wester, C., Wester, C.W., Ogwu, A., Asmelash, A., Musonda, R., Campa, A., Moyo, S., van Widenfelt, E., Mine, M., Moffat, C., Mmalane, M., Makhema, J., Marlink, R., Gilbert, P., Seage, G.R. 3rd, DeGruttola, V., and Essex, M. HIV-1 Subtype C Infected Individuals Maintaining High Viral Load as Potential Targets for the “Test-and-Treat” Approach to Reduce HIV Transmission. PloS One. 5:e10148 (2010).
Plank, R.M., Makhema, J., Kebaabetswe, P., Hussein, F., Leseidi, C., Halperinm D., Bassil, B., Shapiro, R., Lockman, S. Acceptability of infant male circumcision as part of HIV prevention and male reporductive health efforts in Gaborone, Botswana, and surrounding areas. AIDS Behav. Oct;14(5):1198-202. (2010)
Shapiro, R., Hughes, M., Ogwu, A., Kitch, D., Lockman, S., Moffat, C., Makhema, J., Moyo, S., Thior, I., McIntosh, K., van Widenfelt, E., Leidner, J., Powis, K., Asmelash, A., Tumbare, E., Zwerski, S., Sharma, U., Handelsman, E., Mburu, K., Jayeoba, O., Moko, E., Souda, S., Lubega, E., Akhtar, M., Wester, C., Snowden, W., Martinez-Tristani, M., Mazhani, L., Essex, M. Antiretroviral Regimens in Pregnancy and Breast-Feeding in Botswana. N Engl J Med. 362:2282-2294. (2010).
Wester, C.W., Thomas, A.M., Bussmann, H., Moyo, S., Makhema, J.M., Gaolathe, T.,Novitsky, V., Essex, M., DeGruttola, V., and Marlink, R.G. Non-nucleoside reverse transcriptase inhibitor outcomes among combination antiretroviral therapy-treated adults in Botswana. AIDS. Suppl 1:S27–36 (2010).
2009
Bussmann, H., Wester, C.W., Thomas, A., Novitsky, V., Okezie, R., Muzenda, T., Gaolathe, T., Ndwapi, N., Mawoko, N., Widenfelt, E., Moyo, S., Musonda, R., Mine, M., Makhema, J., Moffat, H., Essex, M., DeGruttola, V., and Marlink, R.G. Response to Zidovudine/Didanosine-Containing Combination Antiretroviral Therapy Among HIV-1 Subtype C-Infected Adults in Botswana: Two-Year Outcomes from a Randomized Clinical Trial. J Acquir Immune Defic Syndr. 51:37–46 (2009).
Chen, J.Y., Ogwu, A.C., Svab, P., Lockman, S., Moffat, H.J., Gaolathe, T., Moilwa, S., Størdal, K., Dryden-Peterson, S., Moffat, C., Makhema, J., Essex, M., and Shapiro, R.L. Antiretroviral Treatment Initiation among HIV-Infected Pregnant Women with Low CD4+ Cell Counts in Gaborone, Botswana. J Acquir Immune Defic Syndr. Epub 27 October 2009.
Doualla-Bell, F., Gaolathe, T., Avalos, A., Cloutier, S., Ndwapi, N., Holcroft, C., Moffat., H., Dickinson, D., Essex, M., Wainberg, M.A., Mine, M. Five-year followu up of genotypic resistance pattersn in HIV-1 subtupe C infected patients in Botwswana after failure of thymidine analogue-based regimens. J. of International AIDS Society. 12:25. (2009)
Lingappa, J.R., Kahle E., Mugo, N., Mujugira, A., Magaret, A., Baeten, J., Bukusi, E.A., Cohen, C.R., Katabira, E., Ronald, A., Kiarie, J., Farquhar, C., Stewart, G.J., Makhema, J., Essex, M., Were E., Fife K., deBruyn, G., Gray, G., McIntyre, J., Manongi, R., Kapiga, S., Coetzee, D., Allen, S., Inambao, M., Kayitenkore, K., Karita, E., Kanweka, W., Delany, S., Rees, H., Vwalika, B., Coombs, R.W., Morrow, R., Whittington, W., Corey, L., Wald, A., and Celum, C., for the Partners HSV-2/HIV-1 Transmission Study Team. Characteristics of HIV-1 Discordant Couples Enrolled in a Trial of HSV-2 Suppression to Reduce HIV-1 Transmission: The Partners Study. PLoS ONE. 4:e5272 (2009).
Novitsky, V., Lagakos, S., Herzig, M., Bonney, C., Kebaabetswe, L, Rossenkhan, R., Nkwe, D., Margolin, L., Musonda, R., Moyo, S., Woldegabriel, E., van Widenfelt, E., Makhema, J., and Essex, M. Evolution of Proviral gp120 over the First Year of HIV-1 Subtype C Infection. Virology. 383:47–59 (2009).
Novitsky, V., Wang, R., Margolin, L., Baca, J., Kebaabetswe, L., Rossenkhan, R., Bonney, C., Herzig, M., Nkwe, D., Moyo, S., Musonda, R., Woldegabriel, E., van Widenfelt, E., Makhema, J., Lagakos, S., and Essex, M. Timing Constraints of in Vivo Gag Mutations during Primary HIV-1 Subtype C Infection. PLoS One. 4:e7727 (2009).
Novitsky, V., Wang, R., Kebaabetswe, L., Greenwald, J., Rossenkhan, R., Moyo, S., Musonda, R., Woldegabriel, E., Lagakos, S., and Essex, M. Better Control of Early Viral Replication Is Associated with Slower Rate of Elicited Antiviral Antibodies in the Detuned EIA during Primary HIV-1C Infection. J. Acquir. Immune Defic. Syndr. 52:265–272 (2009). .
Novitsky, V., Woldegabriel, E., Kebaabetswe, L., Rossenkhan, R., Mlotshwa, B., Bonney, C., Herzig, M., Finucane, M., Musonda, R., Moyo, S., Wester, C., van Widenfelt, E., Makhema, J., Lagakos, S., and Essex, M. Viral Load and CD4+ T Cell Dynamics in Primary HIV-1 Subtype C Infection. J. Acquir. Immune Defic. Syndr. 50:65–76 (2009).
Mine, M., Bedi, K., Maruta, T., Madziva, D., Tau, M., Zana, T., Gaolathe, T., Moyo, S., Seipone, K., Ndwapi, N., Essex, M., and Marlink, R. Quantitation of Human Immunodeficiency Virus Type 1 Viral Load in Plasma Using Reverse Transcriptase Activity Assay at a District Hospital Laboratory in Botswana: A Decentralization Pilot Study. J. Virol. Methods. 159:93–97 (2009).
Rossenkhan, R., Ndung’u, T., Sebunya, T., Hagan, J., Shapiro, R., Novitsky, V., Moyo, S.M., Thior, I., Lockman, S., Mitchell, R., Kim, S., Musonda, R., van Widenfelt, E., Makhema, J., and Essex, M. Temporal Reduction of HIV Type 1 Viral Load in Breast Milk by Single-Dose Nevirapine during Prevention of MTCT. AIDS Res. Hum. Retroviruses. 25:1261–4 (2009).
Shapiro, R.L., Smeaton, L., Lockman, S., Thior, I., Rossenkahn, R., Wester, C., Stevens, L., Moffat, C., Arimi, P., Ndase, P., Asmelash, A., Leidner, J., Novitsky, V., Makhema, J., and Essex, M. Risk Factors for Early and Late Transmission of HIV via Breast-Feeding among Infants Born to HIV-Infected Women in a Randomized Clinical Trial in Botswana. J. Infect. Dis. 199:414–418 (2009).
Shipton, L.K., Wester, C.W., Stock, S., Ndwapi, N., Gaolathe, T., Thior, I., Avalos, A., Moffat, H.J., Mboya J.J., Widenfelt, E., Essex, M., Hughes, M.D., and Shapiro, R.L. Safety and Efficacy of Nevirapine and Efavarinz-Based Antiretroviral Treatment in Adults Treated for TB-HIV Co-Infection in Botswana. Int. J. Tuberc. Lung Dis. 13:360–366 (2009).
Wester, C.W., Bussmann, H., Koethe, J., Moffat, C., Vermund, S., Essex, M., and Marlink, R.G. Adult Combination Antiretroviral Therapy in Sub-Saharan Africa: Lessons from Botswana and Future Challenges. HIV Ther. 3:501–526 (2009).
2008
Bae, W.H., Wester, C., Smeaton, L.M., Shapiro, R.L., Lockman, S., Onyait, K., Thior, I., Essex,
M. Hematologic and hepatic toxicities associated with antenatal and postnatal
exposure to maternal highly active antiretroviral therapy among infants. AIDS. Aug 20;22(13):1633-40 (2008).
Bussmann C, Rotz P, Ndwapi N, Baxter D, Bussmann H, Wester CW, Ncube P, Avalos A, Mine M, Mabe E, Burns P, Cardiello P, Makhema J, Marlink R. Strengthening healthcare capacity through a responsive, country-specific, training standard: the KITSO AIDS training program's support of Botswana's national antiretroviral therapy rollout. Open AIDS J. 2008;2:10-6. Epub 2008 Feb 29.
Bussmann, H., Wester, C.W., Ndwapi, N., Grundmann, N., Gaolathe, T., Puvimanasinghe, J., Avalos, A., Mine, M., Seipone, K., Essex, M., deGruttola, V., and Marlink, R.G. Five-Year Outcomes of Initial Patients Treated in Botswana’s National Antiretroviral Treatment Program. AIDS. 22:2303–2311 (2008).
Novitsky, V., Woldegabriel, E., Wester, C., McDonald, E., Rossenkhan, R., Ketunuti, M., Makhema, J., Seage, G.R. 3rd, Essex, M. Identification of primary HIV-1C infection in Botswana. AIDS Care. Aug;20(7):806-11 (2008).
Rowley, C.F., Boutwell, C.L., Lockman, S., Essex, M. Improvement in allele-specific PCR assay with the use of polymorphism-specific primers for the analysis of minor variant drug resistance in HIV-1 subtype C. J Virol Methods.Apr;149(1):69-75. (2008).
2007
Boutwell, C., and Essex, M. Identification of Class I HLA-Associated Amino Acid Polymorphisms in the HIV-1C Proteome. AIDS Res. Hum. Retroviruses. 23:165-174 (2007).
Bussmann, H., Wester, C.W., Wester, C.N., Lekoko, B., Okezie, O., Thomas, A.M., DeGruttola, S.M., Makhema, J., Essex, M., Marlink, R.G. Pregnancy rates and birth outcomes among women on efavirenz-containing highly active antiretroviral therapy in Botswana. J Acquir Immune Defic Syndr. Jul 1;45(3):269-73 (2007).
Lockman, S., Shapiro, R.L., Smeaton, L.M., Wester, C., Thior, I., Stevens, L., Chand, F., Makhema, J., Moffat, C., Asmelash, A., Ndase, P., Arimi, P., van Widenfelt, E., Mazhani, L., Novitsky, V., Lagakos, S., and Essex, M. Response to Antiretroviral Therapy after a Single, Peripartum Dose of Nevirapine. N. Engl. J. Med. 356:135-147 (2007).
Novitsky, V., Wester, C. W., De Gruttola, V., Bussmann, H., Gaseitsiwe, S., Thomas, A., Moyo, S., Musonda, R., van Widenfelt, E., Marlink, R. G., and Essex, M. The Reverse Transcriptase 67N 70R 215Y Genotype Is the Predominant TAM Pathway Associated with Virologic Failure among HIV Type 1C-Infected Adults Treated with ZDV/ddI-Containing HAART in Southern Africa. AIDS Res. Hum. Retroviruses. 23:868-878 (2007).
Novitsky, V., Gaolathe, T., Woldegabriel, E., Makhema, J., and Essex, M. A Seronegative Case of HIV-1 Subtype C Infection in Botswana. Clin. Infect. Dis. 45:e68-71 (2007).
Redd, A.D., Avalos, A., and Essex, M. Infection of Hematopoietic Progenitor Cells by HIV-1 Subtype C, and Its Association with Anemia in Southern Africa. Blood. 110:3143-3149 (2007).
Redd, A.D., Avalos, A., Phiri, K., Essex, M. Effects of HIV type 1 infection on hematopoiesis in Botswana. AIDS Res Hum Retroviruses. Aug;23(8):996-1003 (2007).
Shapiro, R.L., Lockman, S., Kim, S., Smeaton, L., Rahkola, J.T., Thior, I., Wester, C., Moffat, C., Arimi, P., Ndase, P., Asmelash, A., Stevens, L., Montano, M., Makhema, J., Essex, M., Janoff, EN. Infant morbidity, mortality, and breast milk immunologic profiles among breast-feeding HIV-infected and HIV-uninfected women in Botswana. J Infect Dis. Aug 15;196(4):562-9. Epub 2007 Jul 9 (2007).
Thior, I., Gabaitiri, L., Grimes, J., Shapiro, R., Lockman, S., Kim, S., Kebaabetswe, P., Garmey, E., Montano, M., Peter, T., Chang, S.Y., Marlink, R., and Essex M. Voluntary Counseling and Testing among Post-Partum Women in Botswana. Patient Educ. Couns. 65:296-302 (2007).
Wester, C.W., Okezie, O.A., Thomas, A.M., Bussmann, H., Moyo, S., Muzenda, T., Makhema, J., van Widenfelt, E., Musonda, R., Novitsky, V., Gaolathe, T., Ndwapi, N., Essex, M., Kuritzkes, D.R., DeGruttola, V., Marlink, R.G. Higher-than-expected rates of lactic acidosis among highly active antiretroviral therapy-treated women in Botswana: preliminary results from a large randomized clinical trial. J Acquir Immune Defic Syndr. Nov 1;46(3):318-22 (2007).
2006
Brenner, B.G., Oliveira, M., Doualla-Bell, F., Moisi, D.D., Ntemgwa, M., Frankel, F., Essex, M., and Wainberg, M.A. HIV-1 Subtype C Viruses Rapidly Develop K65R Resistance to Tenofovir in Cell Culture. AIDS. 20:F9-F13 (2006).
Bussmann, H., Wester, C.W., Ndwapi, N., Vanderwarker, C., Gaolathe, T., Tirelo, G., Avalos, A., Moffat, H., Marlink, R.G. Hybrid data capture for monitoring patients on highly active antiretroviral therapy (HAART) in urban Botswana. Bull World Health Organ. Feb;84(2):127-31 (2006).
Doualla-Bell, F., Avalos, A., Brenner, B., Gaolathe, T., Mine, M., Gaseitsiwe, S., Oliveira, M., Moisi, D., Ndwapi, N., Moffat, H., Essex, M., Wainberg, M.A. High prevalence of the K65R mutation in human immunodeficiency virus type 1 subtype C isolates from infected patients in Botswana treated with didanosine-based regimens. Antimicrob Agents Chemother. Dec;50(12):4182-5. Epub 2006 Oct 2 (2006).
Doualla-Bell, F., Avalos, A., Gaolathe, T., Mine, M., Gaseitsiwe, S., Ndwapi, N., Novitsky, V., Brenner, B., Oliveira, M., Moisi, D., Moffat, H., Thior, I, Essex, M., and Wainberg, M.A. Impact of Human Immunodeficiency Virus Type 1 Subtype C on Drug Resistance Mutations in Patients from Botswana Failing a Nelfinavir-Containing Regimen. Antimicrob. Agents Chemother. 50:2210-2213 (2006).
Montano, M., Rarick, M., Sebastiani, P., Brinkmann, P., Russell, M., Navis, A., Wester, C., Thior, I., Essex, M. Gene-expression profiling of HIV-1 infection and perinatal transmission in Botswana. Genes Immun. Jun;7(4):298-309. Epub 2006 May 4 (2006).
Ndung’u, T., Sepako, E., McLane, M.F., Chand, F., Bedi, K., Gaseitsiwe, S., Doualla-Bell, F., Peter, T., Thior, I., Moyo, S.M., Gilbert, P., Novitsky, V.A., and Essex, M. HIV-1 Subtype C In Vitro Growth and Coreceptor Utilization. Virology. 347:247-260 (2006).
Nkolola, J.P., and Essex, M. Progress Towards an HIV-1 Subtype C Vaccine. Vaccine. 24:391-401 (2006).
Novitsky, V., Gilbert, P., Shea, K., McLane, M.F., Rybak, N., Klein, I., Thior, I., Ndung’u, T., Lee, T.H., and Essex, M. Interactive Association of Proviral Load and IFN-?–Secreting T Cell Responses in HIV-1C Infection. Virology. 349:142-155 (2006).
Shapiro, R.L., Thior, I., Gilbert, P.B., Lockman, S., Wester, C., Smeaton, L.M., Stevens, L., Heymann, S.J., Ndung'u, T., Gaseitsiwe, S., Novitsky, V., Makhema, J., Lagakos, S., Essex, M. Maternal single-dose nevirapine versus placebo as part of an antiretroviral strategy to prevent mother-to-child HIV transmission in Botswana. AIDS. Jun 12;20(9):1281-8 (2006).
Thior, I., Lockman, S., Smeaton, L.M., Shapiro, R.L., Wester, C., Heymann, S.J., Gilbert, P.B., Stevens, L., Peter, T., Kim, S., van Widenfelt, E., Moffat, C., Ndase, P., Arimi, P., Kebaabetswe, P., Mazonde, P., Makhema, J., McIntosh, K., Novitsky, V., Lee, T.H., Marlink, R., Lagakos, S., Essex, M; Mashi Study Team. Breastfeeding plus infant zidovudine prophylaxis for 6 months vs formula feeding plus infant zidovudine for 1 month to reduce mother-to-child HIV transmission in Botswana: a randomized trial: the Mashi Study. JAMA. Aug 16;296(7):794-805 (2006).
Wester, C.W., Bussmann, H., Moyo, S., Avalos, A., Gaolathe, T., Ndwapi, N., Essex, M., MacGregor, R.R., Marlink, R.G. Serological evidence of HIV-associated infection among HIV-1-infected adults in Botswana. Clin Infect Dis. Dec 15;43(12):1612-5. Epub 2006 Nov 8 (2006).
Wolfe, W.R., Weiser, S.D., Bangsberg, D.R., Thior, I., Makhema, J.M., Dickinson, D.B., Mompati, K.F., Marlink, R.G. Effects of HIV-related stigma among an early sample of patients receiving antiretroviral therapy in Botswana. AIDS Care. Nov;18(8):931-3 (2006).
2005
Bussmann, H., Novitsky, V., Wester, W., Peter, T., Masupu, K., Gabaitiri, L., Kim, S.,
Gaseitsiwe, S., Ndungú, T., Marlink, R., Thior, I., Essex, M.
HIV-1 subtype C drug-resistance background among ARV-naive adults in Botswana. Antivir Chem Chemother. 16(2):103-15 (2005).
Gilbert, P.B., Novitsky, V., and Essex, M. Covariability of Selected Amino Acid Positions for HIV Type 1 Subtypes C and B. AIDS Res. Hum. Retroviruses. 21:1016-1030 (2005).
Ndung'u, T,, Gaseitsiwe, S., Sepako, E., Doualla-Bell, F., Peter, T., Kim, S., Thior, I., Novitsky, V.A., Essex, M. Major histocompatibility complex class II (HLA-DRB and -DQB) allele frequencies in Botswana: association with human immunodeficiency virus type 1 infection. Clin Diagn Lab Immunol. Sep;12(9):1020-8 (2005).
Shapiro, R.L., Holland, D.T., Capparelli, E., Lockman, S., Thior, I., Wester, C., Stevens, L., Peter, T., Essex, M., Connor, J.D., Mirochnick, M. Antiretroviral concentrations in breast-feeding infants of women in Botswana receiving antiretroviral treatment. J Infect Dis. Sep 1;192(5):720-7 (2005).
Shapiro, R.L., Ndung'u, T., Lockman, S., Smeaton, L.M., Thior, I., Wester, C., Stevens, L., Sebetso, G., Gaseitsiwe, S., Peter, T., Essex, M. Highly active antiretroviral therapy started during pregnancy or postpartum suppresses HIV-1 RNA, but not DNA, in breast milk. J Infect Dis Sep 1;192(5):713-9 (2005).
Wester, C.W., Bussmann, H., Avalos, A., Ndwapi, N., Gaolathe, T., Cardiello, P., Bussmann, C., Moffat, H., Mazonde, P., Marlink, R.G. Establishment of a public antiretroviral treatment clinic for adults in urban Botswana: lessons learned. Clin Infect Dis. Apr 1;40(7):1041-4 (2005).
Wester, C.W., Kim, S., Bussmann, H., Avalos, A., Ndwapi, N., Peter, T.F., Gaolathe, T., Mujugira, A., Busang, L., Vanderwarker, C., Cardiello, P., Johnson, O., Thior, I., Mazonde, P., Moffat, H., Essex, M., Marlink, R. Initial response to highly active antiretroviral therapy in HIV-1C-infected adults in a public sector treatment program in Botswana. J Acquir Immune Defic Syndr. Nov 1;40(3):336-43 (2005).
2004
Bussmann, H., Wester, C.W., Masupu, K.V., Peter, T., Gaolekwe, S.M., Kim, S., Reich, AM., Ahn,
S., Wu, Y., Thior, I., Essex, M., Marlink, R. Low CD4+ T-lymphocyte values in human immunodeficiency virus-negative adults in
Botswana. Clin Diagn Lab Immunol. Sep;11(5):930-5 (2004).
Doualla-Bell, F., Gaseitsiwe, S., Ndungú, T., Modukanele, M., Peter, T., Novitsky, V., Ndwapi, N., Tendani, G., Avalos, A., Wester, W., Bussmann, H., Cardiello, P., Marlink, R., Moffat, H., Thior, I., Wainberg, M.A., Essex, M. Mutations and polymorphisms associated with antiretroviral drugs in HIV-1C-infected African patients. Antivir Chem Chemother. Jul;15(4):189-200 (2004).
Doualla-Bell, F., Gaseitsiwe, S., Ndung’u, T., Modukanele, M., Peter, T., Novitsky, V., Ndwapi, N., Gaolathe, T., Avalos, A., Wester, W., Bussmann, H., Cardiello, P., Marlink, R., Moffatt, H., Thior, I., Wainberg, M.A., and Essex, M. Mutations and Polymorphisms Associated with Antiretroviral Drugs in HIV-1C-Infected African Patients. Antivir. Chem. Chemother. 15:189-200 (2004).
2003
Kebaabetswe, P., Lockman, S., Mogwe, S., Mandevu, R., Thior, I., Essex, M., Shapiro, R.L.
Male circumcision: an acceptable strategy for HIV prevention in Botswana. Sex Transm Infect. Jun;79(3):214-9 (2003).
Lockman, S., Hone, N., Kenyon, T.A., Mwasekaga, M., Villauthapillai, M., Creek, T., Zell, E., Kirby, A., Thacker, W.L., Talkington, D., Moura, I.N., Binkin, N.J., Clay, L., Tappero, J.W. Etiology of pulmonary infections in predominantly HIV-infected adults with suspected tuberculosis, Botswana. Int J Tuberc Lung Dis. Aug;7(8):714-23 (2003).
Loemba, H., Brenner, B., Parniak, M.A., Ma'ayan, S., Spira, B., Moisi, D., Oliveira, M., Detorio, M., Essex, M., Wainberg, M.A. Polymorphisms of cytotoxic T-lymphocyte (CTL) and T-helper epitopes within reverse transcriptase (RT) of HIV-1 subtype C from Ethiopia and Botswana following selection of antiretroviral drug resistance. Antiviral Res. Nov;56(2):129-42 (2003).
Montano, M., Russell, M., Gilbert, P., Thior, I., Lockman, S., Shapiro, R., Chang, S.Y., Lee, T.H., Essex, M. Comparative prediction of perinatal human immunodeficiency virus type 1 transmission, using multiple virus load markers. J Infect Dis. Aug 1;188(3):406-13 (2003).
Novitsky, V., Gilbert, P., Peter, T., McLane, M.F., Gaolekwe, S., Rybak, N., Thior, I., Ndung’u, T., Marlink, R., Lee, T.H., and Essex, M. Association between Virus-Specific CTL Responses and Plasma Viral Load in Human Immunodeficiency Virus Type 1 Subtype C Infection. J. Virol. 77:882-890 (2003).
Shapiro, R.L., Lockman, S., Thior, I., Stocking, L., Kebaabetswe, P., Wester, C., Peter, T., Marlink, R., Essex, M., Heymann, S.J. Low adherence to recommended infant feeding strategies among HIV-infected women: results from the pilot phase of a randomized trial to prevent mother-to-child transmission in Botswana. AIDS Educ Prev. Jun;15(3):221-30 (2003).
Quan, Y., Brenner, B., Marlink, R., Essex, M., Kurimura, T., and Wainberg, M. Drug Resistance Profiles of Recombinant Reverse Transcriptases from HIV-1 Subtypes A/E, B, and C. AIDS Res. Hum. Retroviruses 19:743-753 (2003).
Weiser, S., Wolfe, W., Bangsberg, D., Thior, I., Gilbert, P., Makhema, J., Kebaabetswe, P., Dickenson, D., Mompati, K., Essex, M., Marlink, R. Barriers to antiretroviral adherence for patients living with HIV infection and AIDS in Botswana. J Acquir Immune Defic Syndr. Nov 1;34(3):281-8 (2003).
2002
Kenyon, T.A., Creek, T., Laserson, K., Makhoa, M., Chimidza, N., Mwasekaga, M., Tappero, J.,
Lockman, S., Moeti, T., Binkin, N.
Risk factors for transmission of Mycobacterium tuberculosis from HIV-infected
tuberculosis patients, Botswana. Int J Tuberc Lung Dis. Oct;6(10):843-50 (2002).
Novitsky, V., Cao, H., Rybak, N., Gilbert, P., McLane, M.F., Gaolekwe, S., Peter, T., Thior, I., Ndung’u, T., Marlink, R., Lee, T.H., and Essex, M. Magnitude and Frequency of CTL Responses: Identification of Immunodominant Regions in HIV-1 Subtype C. J. Virol. 76:10155-10168 (2002).
Novitsky, V., Smith, U.R., Gilbert, P., McLane, M.F., Chigwedere, P., Williamson, C., Ndung’u, T., Klein, I., Chang, S.Y., Peter, T., Thior, I., Foley, B.T., Gaolekwe, S., Rybak, N., Gaseitsiwe, S., Vannberg, F., Marlink, R., Lee, T.H., and Essex, M. Human Immunodeficiency Virus Type 1 Subtype C Molecular Phylogeny: Consensus Sequence for an AIDS Vaccine Design? J. Virol. 76:5435-5451 (2002).
2001
Ndung’u, T., Lu, Y., Renjifo, B., Touzjian, N., Kushner, N., Pena-Cruz, V., Novitsky, V., Lee, T.H., and Essex, M. An Infectious Simian/Human Immunodeficiency Virus with Human Immunodeficiency Virus Type 1 Subtype C from an African Isolate: Rhesus Macaque Model. J. Virol. 75:11417-11425 (2001).
Ndung'u, T., Renjifo, B., and Essex, M. Construction and Analysis of an Infectious Human Immunodeficiency Virus Type 1 Subtype C Molecular Clone. J. Virol. 75:4964-4972 (2001).
Novitsky V, Flores-Villanueva PO, Chigwedere P, Gaolekwe S, Bussman H, Sebetso G, Marlink R, Yunis EJ, Essex M. Identification of most frequent HLA class I antigen specificities in Botswana: relevance for HIV vaccine design. Hum Immunol. 2001 Feb;62(2):146-56.
Novitsky, V., Rybak, N., McLane, M.F., Gilbert, P., Chigwedere, P., Klein, I., Gaolekwe, S., Chang, S.Y., Peter, T., Thior, I., Ndung’u, T., Vannberg, F., Foley, B.T., Marlink, R., Lee, T.H., and Essex M. Identification of HIV-1C Gag-, Tat-, Rev-, and Nef-specific Elispot-based CTL Responses for AIDS Vaccine Design. J. Virol. 75:9210-9228 (2001).
2000
Montano, M.A., Nixon, C.P., Ndung'u, T., Bussmann, H., Novitsky, V.A., Dickman, D., Essex, M.
Elevated tumor necrosis factor-alpha activation of human immunodeficiency virus
type 1 subtype C in Southern Africa is associated with an NF-kappaB enhancer
gain-of-function. J Infect Dis. Jan;181(1):76-81 (2000).
Ndung'u, T., Renjifo, B., Novitsky, V.A., McLane, M.F., Gaolekwe, S., Essex, M. Molecular cloning and biological characterization of full-length HIV-1 subtype C from Botswana. Virology. Dec 20;278(2):390-9 (2000).
Novitsky, V.A., Gaolekwe, S., McLane, M.F., Ndung'u, T.P., Foley, B.T., Vannberg, F., Marlink, R., and Essex, M. HIV-1 A/J Recombinant with a Pronounced pol Gene Mosaicism. AIDS Res. Hum. Retroviruses 16:1015-1020 (2000).
1999
Novitsky, V.A., Montano, M.A., McLane, M.F., Renjifo, B., Vannberg, F., Foley, B.T., Ndung'u,
T.P., Rahman, M., Makhema, M.J., Marlink, R., Essex, M. Molecular cloning and phylogenetic analysis of human immunodeficiency virus type
1 subtype C: a set of 23 full-length clones from Botswana.
J Virol. May;73(5):4427-32 (1999).
 |
| Prof. Phyllis Kanki, the Chief of Kuramo, and Pastor Toju-Tubi with people from Kuramo in front of the new site for the VCT Clinic. |
Researchers have developed collaborative HIV prevention programs through the AIDS Prevention Initiative in Nigeria (APIN), lead by Professor Phyllis Kanki. APIN is committed to providing critical support aimed at strengthening both the leadership and scientific capacity needed to defeat Nigeria's AIDS epidemic.
In February 2004, Professor Kanki also became principal investigator of a U.S. President's Emergency Plan for AIDS Relief (PEPFAR) grant to help eradicate HIV in the world's hardest-hit regions. The grant is being used to expand antiretroviral therapy programs for HIV-infected people in Nigeria, Botswana, and Tanzania. The Nigerian portion of the program—called "APIN Plus"—is now bolstering the nation's antiretroviral program.
2013
Dinic L, Idigbe OE, Meloni S, Rawizza H, Akande P, Eisen G, Onwujekwe D, Agbaji O, Ani A, Kanki PJ. Sputum smear concentration may misidentify acid-fast bacilli as Mycobacterium tuberculosis (Mtb) in HIV-infected patients. J Acquir Immune Defic Syndr. 2013 Feb 7.
Akanbi MO, Achenbach C, Feinglass J, Taiwo B, Adamu O, Mai P, Agbaji O, Kanki PJ, Murphy R Tuberculosis after One Year of Combination Antiretroviral Therapy in Nigeria. AIDS Res Hum Retroviruses. 2013 Jan 15.
2012
Agbaji O, Thio CL, Meloni S, Graham C, Muazu M, Nimzing L, Idoko J, Sankalé JL, Ekong E, Murphy R, Kanki P, Hawkins C. Impact of Hepatitis C Virus on HIV Response to Antiretroviral Therapy in Nigeria. J Acquir Immune Defic Syndr. 2012 Nov 28.
2011
Rawizza, H.E., Chaplin, B., Meloni, S.T., Eisen, G., Rao, T., Sankalé, J.L., Dieng-Sarr, A., Agbaj,i O., Onwujekwe, D.I., Gashau, W., Nkado, R., Ekong, E., Okonkwo, P., Murphy, R.L., Kanki, P.J.; for the APIN PEPFAR Team. Immunologic Criteria Are Poor Predictors of Virologic Outcome: Implications for HIV Treatment Monitoring in Resource-Limited Settings. Clin Infect Dis. 2011 Dec;53(12):1283-1290.
Agaba. P.A., Digin, E., Makai, R., Apena, L., Agbaji, O.O., Idoko, J.A., Murphy, R., Kanki, P. Clinical characteristics and predictors of mortality in hospitalized HIV-infected Nigerians. J Infect Dev Ctries. May 28;5(5):377-82. (2011)
Chaplin B, Eisen G, Idoko J, Onwujekwe D, Idigbe E, Adewole I, Gashau W, Meloni S, Sarr AD, Sankalé JL, Ekong E, Murphy RL, Kanki P. Impact of HIV type 1 subtype on drug resistance mutations in Nigerian patients failing first-line therapy. AIDS Res Hum Retroviruses. Jan;27(1):71-80. Epub 2010 Oct 21.(2011)
2010
Akinyemi JO, Awolude OA, Adewole IF, Kanki PJ. Condom use among antiretroviral therapy patients in Ibadan, Nigeria.
J Infect Dev Ctries. 2010 Sep 3;4(8):495-502.
Oladokun RE, Awolude O, Brown BJ, Adesina O, Oladokun A, Roberts A, Odaibo G, Osinusi K, Olaleye D, Adewole IF, Kanki P. Service uptake and performance of the prevention of mother-to-child transmission (PMTCT) programme in Ibadan, Nigeria. Afr J Med Med Sci. 2010 Jun;39(2):81-7.
Taiwo B, Chaplin B, Penugonda S, Meloni S, Akanmu S, Gashau W, Idoko J, Adewole I, Murphy R, Kanki P. Suboptimal etravirine activity is common during failure of nevirapine-based combination antiretroviral therapy in a cohort infected with non-B subtype HIV-1. Curr HIV Res. 2010 Apr 1;8(3):194-8.
2009
Agaba PA, Sule HM, Ojoh RO, Hassan Z, Apena L, Mu'azu MA, Badung B, Agbaji OO, Idoko JA, Kanki P. Presentation and survival of patients with AIDS-related Kaposi's sarcoma in Jos, Nigeria. Int J STD AIDS. 2009 Jun;20(6):410-3.
Hawkins CA, Chaplin B, Idoko J, Ekong E, Adewole I, Gashau W, Murphy RL, Kanki P; APIN Plus/Harvard PEPFAR Team. Clinical and genotypic findings in HIV-infected patients with the K65R mutation failing first-line antiretroviral therapy in Nigeria. J Acquir Immune Defic Syndr. 2009 Oct 1;52(2):228-34.
Idoko J, Meloni S, Muazu M, Nimzing L, Badung B, Hawkins C, Sankalé JL, Ekong E, Murphy R, Kanki P, Thio CL. Impact of hepatitis B virus infection on human immunodeficiency virus response to antiretroviral therapy in Nigeria. Clin Infect Dis. 2009 Oct 15;49(8):1268-73.
2008
Ojesina, AI., Chaplin, B., Sankale, JL., Murphy, R., Idigbe, E., Adewole, I., Ekong, E., Idoko, J., Kanki, PJ. Interplay of Reverse Transcriptase Inhibitor Therapy and Gag p6 Diversity in HIV Type 1 Subtype G and CRF02_AG. AIDS Res. Hum. Retroviruses. Sep; 24(9): 1167-74 (2008)
Otegbayo JA, Taiwo BO, Akingbola TS, Odaibo GN, Adedapo KS, Penugonda S, Adewole IF, Olaleye DO, Murphy R, Kanki P. Prevalence of hepatitis B and C seropositivity in a Nigerian cohort of HIV-infected patients. Ann Hepatol. Apr-Jun;7(2):152-6. (2008)2007
2007
Idoko, J.A., Agbaji, O., Agaba, P., Akolo, C., Inuwa, B., Hassan, Z., Akintunde, L., Badung,
B., Muazu, M., Danang, M., Imade, G., Sankale, J.L., Kanki, P.
Direct observation therapy-highly active antiretroviral therapy in a
resource-limited setting: the use of community treatment support can be
effective. Int. J. STD AIDS. Nov;18(11):760-3 (2007)
Ladep, N.G., Agbaji, O., Agaba, P., Badung, P., Imade, G., Sankalé, J., Idoko, J., Kanki, P. Does immunological status affect the prevalence of Hepatitis C virus infection among HIV/AIDS patients? Niger. J Med. Jul-Sep;16(3):231-4 (2007)
Ojesina, AI., Mullins, C., Imade, G., Samuels, J., Sankale, JL., Pam, S., Sagay, S., Idoko, J., Kanki, PJ. Characterization of HIV type 1 reverse transcriptase mutations in infants infected by mothers who received peripartum nevirapine prophylaxis in Jos, Nigeria. AIDS. Res. Hum. Retroviruses. Dec; 23(12):1587-92 (2007)
Sankale, JL., Langevin, S., Odaibo, G., Meloni, ST., Ojesina, AI., Olaleye, D., Kanki, P. The complexity of circulating HIV type 1 strains in Oyo state, Nigeria. AIDS. Res. Hum. Retroviruses. Aug; 23(8): 1020-5 (2007)
2006
Ojesina, A.I., Kanki, P.J.
HIV-1 subtype and reverse transcriptase genotype: role for geographical location
and founder effects.
PLoS Med. Dec;3(12):e540. (2006). No abstract available.
Ojesina, AI., Sankale, JL., Odaibo, G., Langevin, S., Meloni, ST., Sarr, AD., Olaleye, D., Kanki, PJ. Subtype-specific patterns in HIV Type 1 reverse transcriptase and protease in Oyo State, Nigeria: implications for drug resistance and host response. AIDS. Res. Hum. Retroviruses. Aug; 22(8): 770-9 (2006)
Sagay, A.S., Musa, J., Adewole, A.S.,. Imade, G.E., Ekwempu, C.C., Kapiga, S., Sankale, J.L., Idoko, J., Kanki, P. Rapid HIV testing and counselling in labour in a northern Nigerian setting. Afr J Reprod Health. Apr;10(1):76-80 (2006)
Sagay, A.S., Musa, J., Ekwempu, C.C., Imade, G.E., Babalola, A., Daniyan, G., Malu, N., Idoko, J.A., Kanki, P. Partner disclosure of HIV status among HIV positive mothers in Northern Nigeria. Afr. J. Med. Med. Sci. Dec;35 Suppl:119-23 (2006)
2005
Idigbe, E.O., Adewole, T.A., Eisen, G., Kanki, P., Odunukwe, N.N., Onwujekwe, D.I., Audu, R.A.,
Araoyinbo, I.D., Onyewuche, J.I., Salu, O.B., Adedoyin, J.A., Musa, A.Z.
Management of HIV-1 infection with a combination of nevirapine, stavudine, and
lamivudine: a preliminary report on the Nigerian antiretroviral program. J Acquir Immune Defic Syndr. Sep 1;40(1):65-9 (2005).
Sagay, A.S., Kapiga, S.H., Imade, G.E., Sankale, J.L., Idoko, J., Kanki, P. HIV infection among pregnant women in Nigeria. Int J Gynaecol Obstet. Jul;90(1):61-7 (2005)
2000
Dieng Sarr, A., Sankalé, J.-L., Guèye-Ndiaye, A., Essex, M., Mboup, S., and Kanki, P.J. Genetic Analysis of HIV-2 in Monotypic and Dual HIV Infections. AIDS Res. Hum. Retroviruses 16:295-298 (2000).
Kokkotou, E.G., Sankale, J.L, Mani, I., Gueye-Ndiaye, A., Schwartz, D., Essex, M., Mboup, S. and Kanki, P.J. In Vitro Correlates of HIV-2 Mediated HIV-1 Protection. Proc. Natl. Acad. Sci. 97:6797-6802 (2000).
Popper, S.J., Dieng-Sarr, A., Gueye-Ndiaye, A., Mboup, S., Essex, M.E., Kanki, P.J. Low Plasma HIV-2 Viral Load is Independent of Proviral Load: Low Virus Production in Vivo. J. Virol. 74:1554-1557 (2000).
1999
Dieng Sarr, A., Popper, S., Thior, I., Sankalé, J.-L., Siby, T., Marlink, R., Essex, M., Ndoye, I., Coll Seck, E.M., Mboup, S., and Kanki, P.J. Relationship Between HIV-2 Proviral Load and CD4+ Lymphocyte Count Differs in HIV Monotypic and Dual Infections. J. Hum.Virol. 2:45-51 (1999).
1998
Sankalé, J.-L., MBoup, S., Essex, M., and Kanki, P.J. Genetic Characterization of Viral Quasispecies in Blood and Cervical Secretions of HIV-1 and HIV-2 Infected Women. AIDS Res. Hum. Retroviruses. 14:1473-1481 (1998).
Popper, S.J., Sankalé, J-L., Thior, I., Siby, T. Marlink, R.G., Mboup, S., Essex, M., and Kanki, P. Antibodies to the HIV Type 2 Core Protein p26 and Vpx: Association with Disease Progression. AIDS Res. Hum. Retroviruses. 14:1157-1162 (1998).
Dieng-Sarr, A., Hamel, D.G., Travers, K.U., Kokkotou, E., Sankalé, J.-L., Marlink, R., Coll-Seck, E.M., Essex, M., Siby, T., NDoye, I., MBoup, S., and Kanki, P.J. HIV-1 and HIV-2 dual infection: lack of HIV-2 proviral correlates with Low CD4+ lymphocyte counts. AIDS, 12:131-137 (1998).
Travers, K., Eisen, G., Marlink, R., Essex, M., Hsieh, C.C., Mboup, S., Kanki, P.J. Protection from HIV-1 Infection by HIV-2. AIDS. 12:224-226 (1998).
1996
Sankalé, J.-L., Sallier de la Tour, R., Marlink, R.G., Scheib, R., Mboup, S., Essex, M.E., and Kanki, P.J. Distinct Quasi-Species in the Blood and the Brain of an HIV-2 Infected Individual. Virol. 226:418-423 (1996).
1995
Sankalé, J.-L., Sallier de la Tour, R., Renjifo, B., Siby, T., Mboup, S., Marlink, R.G., Essex, M.E., and Kanki, P.J. Intrapatient Variability of the Human Immunodeficiency Virus Type 2 Envelope V3 Loop. AIDS Res. Hum. Retroviruses 11:617-623 (1995).
1993
Guèye-Ndiaye, A., Clark, R.J., Samuel, K.P., Ndour-Sarr, A.N., Ouangré, A., Sangaré, L., Mboup, S., Marlink, R.G., Papas, T.S., Child, R.H., Coll-Seck, A.M., Essex, M.E., and Kanki, P.J. Cost-Effective Diagnosis of HIV-1 and HIV-2 by Recombinant-Expressed env Peptide (566/996) Dot Blot Analysis. AIDS 7: 475-481 (1993).
1992
Kanki, P.J., M'Boup, S., Marlink, R., Travers, K., Hsieh, C.-C., Guèye, A., Boye, C., Sankale, J.-L., Donnelly, C., Leisenring, W., Siby, T., Thior, I., Dia, M., Gueye, E.-H., N'Doye, I., and Essex, M. Prevalence and Risk Determinants of Human Immunodeficiency Virus Type 2 (HIV-2) and Human Immunodeficiency Virus Type 1 (HIV-1) in West African Female Prostitutes. Am. J. Epidemiol. 136:895-907 (1992).
1991
Baillou, A., Janvier, B., Mayer, R., Kanki, P., M'Boup, S., Denis, F., Goudeau, A., Essex, M., and Barin, F. Site-Directed Serology Using Synthetic Oligopeptides Representing the C-Terminus of the External Glycoproteins of HIV-1, HIV-2, or SIVMAC May Distinguish Subtypes among Primate Lentiviruses. AIDS Res. Hum. Retroviruses 7: 767-771 (1991).
1990
Essex, M., Kanki, P.J., Marlink, R., Chou, M.-J., and Lee, T.H. Antigenic Characterization of the Human Immunodeficiency Viruses. J. Am. Acad. Dermatol. 22:1206-1210 (1990).
1990
Romieu, I., Marlink, R., Kanki, P., M'Boup, S., and Essex, M. HIV-2 Link to AIDS in West Africa. J. Acq. Immun. Defic. Syndrome 3:220-230 (1990).
1988
Yu, X.-F., Ito, S., Essex, M., and Lee, T.H. A Naturally Immunogenic Virion-Associated Protein Specific for HIV-2 and SIV. Nature 335:262-265 (1988).
1987
Kanki, P.J., Hopper, J.R. and Essex, M. The Origins of HIV-1 and HTLV-4/HIV-2. Ann. N.Y. Acad. Sci. 511: 370-375 (1987).
Kanki, P.J., M'Boup, S., Ricard, D., Barin, F., Denis, F., Boye, C., Sangare, L., Travers, K., Albaum, M., Marlink, R., Romet-Lemonne, J.-L., and Essex, M. Human T-Lymphotropic Virus Type 4 and the Human Immunodeficiency Virus in West Africa. Science 236:827-831 (1987).
Marlink, R.G. and Essex, M. Africa and the Biology of Human Immunodeficiency Virus. JAMA 257:2632-2633 (1987).
Kanki, P.J., Barin, F., M'Boup, S., and Essex, M. Relationship of Simian T-Lymphotropic Virus Type III to Human Retroviruses in Africa. Antibiot. Chemother. 38:21-27 (1987).
Kanki, P.J., Allan, J., Barin, F., Redfield, R., Clumeck, N., Quinn, T., Mowovondi, F., Thiry, L., Burny, A., Zagury, D., Petat, E., Kocheleff, P., Pascal, K., Lausen, I., Fredericksen, B., Craighead, J., M'Boup, S., Denis, F., Curran, J.W., Mann, J., Francis, H., Albaum, M., Travers, K., McLane, M.F., Lee, T.H., and Essex, M. Absence of Antibodies to HIV-2/HTLV-4 in Six Central African Nations. AIDS Res. Hum. Retroviruses 3:317-322 (1987).
Barin, F., Denis, F., Baillou, A., Leonard, G., Mounier, M., M'Boup, S., Gershy-Damet, G., Sangare, A., Kanki, P., and Essex, M. A STLV-III Related Human Retrovirus, HTLV-IV: Analysis of Cross-Reactivity with the Human Immunodeficiency Virus (HIV). J. Virol. Meth. 17:55-61 (1987).
1985
Barin, F., M'Boup, S., Denis, F., Kanki, P., Allan, J.S., Lee, T.H., and Essex, M. Serological Evidence for Virus Related to Simian T-Lymphotropic Retrovirus III in Residents of West Africa. Lancet ii:1387-1389 (1985).
 |
| Kilimanjaro Christian Medical Centre (KCMC) –Biotechnology laboratory with the view of Mt Kilimanjaro. |
Tanzania has been a major African site for Harvard-sponsored nutritional intervention studies,
and through clinical trails the widest range of HIV subtypes discovered in any African country has been identified in Tanzania. Currently, more than 1,500 mother-infant pairs have completed intervention trials in the country. Studies are now expanding to northern Tanzania to address HIV/AIDS in rural communities and small hospitals.
2011
Ao TT, Sam N, Kiwelu I, Mahal A, Subramanian SV, Wyshak G, Kapiga S.
Risk Factors of Alcohol Problem Drinking Among Female Bar/Hotel Workers in Moshi, Tanzania: A Multi-level Analysis. AIDS Behav. 2011 Feb;15(2):330-9.
Mwiru RS, Spiegelman D, Duggan C, Peterson K, Liu E, Msamanga G, Aboud S, Fawzi WW. Relationship of exclusive breast-feeding to infections and growth of Tanzanian children born to HIV-infected women. Public Health Nutr. 2011 Feb 16:1-8. [Epub ahead of print]
2010
Arsenault JE, Aboud S, Manji KP, Fawzi WW, Villamor E. Vitamin supplementation increases risk of subclinical mastitis in HIV-infected women. J Nutr. 2010 Oct;140(10):1788-92. Epub 2010 Aug 25.
Arsenault JE, Webb AL, Koulinska IN, Aboud S, Fawzi WW, Villamor E. Association between breast milk erythropoietin and reduced risk of mother-to-child transmission of HIV. J Infect Dis. 2010 Aug 15;202(3):370-3.
Baeten JM, Donnell D, Kapiga SH, Ronald A, John-Stewart G, Inambao M, Manongi R, Vwalika B, Celum C; Partners in Prevention HSV/HIV Transmission Study Team. Male circumcision and risk of male-to-female HIV-1 transmission: a multinational prospective study in African HIV-1-serodiscordant couples. AIDS. 2010 Mar 13;24(5):737-44.
Doyle AM, Ross DA, Maganja K, Baisley K, Masesa C, Andreasen A, Plummer ML, Obasi AI, Weiss HA, Kapiga S, Watson-Jones D, Changalucha J, Hayes RJ; MEMA kwa Vijana Trial Study Group. Long-term biological and behavioural impact of an adolescent sexual health intervention in Tanzania: follow-up survey of the community-based MEMA kwa Vijana Trial. PLoS Med. 2010 Jun 8;7(6):e1000287.
Fisher JC, Cook PA, Kapiga SH. Alcohol use before sex and HIV risk: situational characteristics of protected and unprotected encounters among high-risk African women. Sex Transm Dis. 2010 Sep;37(9):571-8.
Franke MF, Spiegelman D, Ezeamama A, Aboud S, Msamanga GI, Mehta S, Fawzi WW. Malaria parasitemia and CD4 T cell count, viral load, and adverse HIV outcomes among HIV-infected pregnant women in Tanzania. Am J Trop Med Hyg. 2010 Apr;82(4):556-62.
Hayes R, Kapiga S, Padian N, McCormack S, Wasserheit J. HIV prevention research: taking stock and the way forward. AIDS. 2010 Oct;24 Suppl 4:S81-92.
Kawai K, Msamanga G, Manji K, Villamor E, Bosch RJ, Hertzmark E, Fawzi WW. Sex differences in the effects of maternal vitamin supplements on mortality and morbidity among children born to HIV-infected women in Tanzania. Br J Nutr. 2010 Jun;103(12):1784-91. Epub 2010 Mar 9.
McCormack S, Ramjee G, Kamali A, Rees H, Crook AM, Gafos M, Jentsch U, Pool R, Chisembele M, Kapiga S, Mutemwa R, Vallely A, Palanee T, Sookrajh Y, Lacey CJ, Darbyshire J, Grosskurth H, Profy A, Nunn A, Hayes R, Weber J. PRO2000 vaginal gel for prevention of HIV-1 infection (Microbicides Development Programme 301): a phase 3, randomised, double-blind, parallel-group trial. Lancet. 2010 Oct 16;376(9749):1329-37. Epub 2010 Sep 17. Mehta S, Fawzi WW.
Mehta S, Fawzi WW. Micronutrient Supplementation as Adjunct Treatment for HIV-Infected Patients. Clin Infect Dis. 2010 Jun 15;50(12):1661-3. No abstract available.
Mehta S, Giovannucci E, Mugusi FM, Spiegelman D, Aboud S, Hertzmark E, Msamanga GI, Hunter D, Fawzi WW. Vitamin D status of HIV-infected women and its association with HIV disease progression, anemia, and mortality. PLoS One. 2010 Jan 19;5(1):e8770.
Mehta S, Spiegelman D, Aboud S, Giovannucci EL, Msamanga GI, Hertzmark E, Mugusi FM, Hunter DJ, Fawzi WW. Lipid-soluble vitamins A, D, and E in HIV-infected pregnant women in Tanzania. Eur J Clin Nutr. 2010 Aug;64(8):808-17. Epub 2010 Jun 2.
Rosenheck R, Ngilangwa D, Manongi R, Kapiga S. Treatment-seeking behavior for sexually transmitted infections in a high-risk population. AIDS Care. 2010 Nov;22(11):1350-8.
Shankar AH, Fawzi WW. Moving toward hematological predictors of disease severity in malaria: going with the flow. Am J Hematol. 2010 Apr;85(4):225-6. No abstract available.
Villamor E, Koulinska IN, Aboud S, Murrin C, Bosch RJ, Manji KP, Fawzi WW. Effect of vitamin supplements on HIV shedding in breast milk. Am J Clin Nutr. 2010 Oct;92(4):881-6. Epub 2010 Aug 25.
2009
Aboud S, Msamanga G, Read JS, Wang L, Mfalila C, Sharma U, Martinson F, Taha TE, Goldenberg RL, Fawzi WW. Effect of prenatal and perinatal antibiotics on maternal health in Malawi, Tanzania, and Zambia. Int J Gynaecol Obstet. 2009 Dec;107(3):202-7. Epub 2009 Aug 28.
Chatterjee A, Bosch RJ, Hunter DJ, Manji K, Msamanga GI, Fawzi WW. Vitamin A and vitamin B-12 concentrations in relation to mortality and morbidity among children born to HIV-infected women. J Trop Pediatr. 2010 Feb;56(1):27-35. Epub 2009 Jun 5.
Chatterjee A, Bosch RJ, Kupka R, Hunter DJ, Msamanga GI, Fawzi WW. Predictors and consequences of anaemia among antiretroviral-naïve HIV-infected and HIV-uninfected children in Tanzania. Public Health Nutr. 2010 Feb;13(2):289-96. Epub 2009 Aug 4.
Isanaka S, Duggan C, Fawzi WW. Patterns of postnatal growth in HIV-infected and HIV-exposed children. Nutr Rev. June; 67(6):343-359. 2009.
Kafulafula G, Mwatha A, Chen YQ, Aboud S, Martinson F, Hoffman I, Fawzi W, Read JS, Valentine M, Mwinga K, Goldenberg R, Taha TE. Intrapartum antibiotic exposure and early neonatal, morbidity, and mortality in Africa. Pediatrics. 2009 Jul;124(1):e137-44.
Kapiga S, Kelly C, Weiss S, Daley T, Peterson L, Leburg C, Ramjee G. Risk factors for incidence of sexually transmitted infections among women in South Africa, Tanzania, and Zambia: results from HPTN 055 study. Sex Transm Dis. 2009 Apr;36(4):199-206.
Kawai K, Kupka R, Mugusi F, Aboud S, Okuma J, Villamor E, Spiegelman D, Fawzi WW. A randomized trial to determine the optimal dosage of multivitamin supplements to reduce adverse pregnancy outcomes among HIV-infected women in Tanzania. Am J Clin Nutr. 2010 Feb;91(2):391-7. Epub 2009 Nov 25.
Kilewo C, Natchu UC, Young A, Donnell D, Brown E, Read JS, Sharma U, Chi BH, Goldenberg R, Hoffman I, Taha TE, Fawzi WW. Hypertension in pregnancy among HIV-infected women in sub-Saharan Africa: prevalence and infant outcomes. Afr J Reprod Health. 2009 Dec;13(4):25-36.
Kupka R, Kassaye T, Saathoff E, Hertzmark E, Msamanga GI, Fawzi WW. Predictors of stillbirth among HIV-infected Tanzanian women. Acta Obstet Gynecol Scand. 2009;88(5):584-92.
Kupka R, Msamanga GI, Aboud S, Manji KP, Duggan C, Fawzi WW. Patterns and predictors of CD4 T-cell counts among children born to HIV-infected women in Tanzania. J Trop Pediatr. 2009 Oct;55(5):290-6. Epub 2009 Jan 21.
Kupka R, Mugusi F, Aboud S, Hertzmark E, Spiegelman D, Fawzi WW. Effect of selenium supplements on hemoglobin concentration and morbidity among HIV-1-infected Tanzanian women. Clin Infect Dis. 2009 May 15;48(10):1475-8.
Mehta S, Hunter DJ, Mugusi FM, Spiegelman D, Manji KP, Giovannucci EL, Hertzmark E, Msamanga GI, Fawzi WW. Perinatal outcomes, including mother-to-child transmission of HIV, and child mortality and their association with maternal vitamin D status in Tanzania. J Infect Dis. 2009 Oct 1;200(7):1022-30.
Msamanga GI, Taha TE, Young AM, Brown ER, Hoffman IF, Read JS, Mudenda V, Goldenberg RL, Sharma U, Sinkala M, Fawzi WW. Placental malaria and mother-to-child transmission of human immunodeficiency virus-1. Am J Trop Med Hyg. 2009 Apr;80(4):508-15.
Msamanga G, Tchetgen E, Spiegelman D, Fawzi MK, Kaaya S, Urassa W, Hunter D, Kapiga S, Fawzi W. Determinants of condom use among antenatal clinic attendees in Dar es Salaam, Tanzania. East Afr J Public Health. 2009 Aug;6(2):175-83.
Nel AM, Coplan P, van de Wijgert JH, Kapiga SH, von Mollendorf C, Geubbels E, Vyankandondera J, Rees HV, Masenga G, Kiwelu I, Moyes J, Smythe SC. Safety, tolerability, and systemic absorption of dapivirine vaginal microbicide gel in healthy, HIV-negative women. AIDS. 2009 Jul 31;23(12):1531-8.
Nelson JA, Loftis AM, Kamwendo D, Fawzi WW, Taha TE, Goldenberg RL, Fiscus SA. Nevirapine resistance in human immunodeficiency virus type 1-positive infants determined using dried blood spots stored for up to six years at room temperature. J Clin Microbiol. 2009 Apr;47(4):1209-11. Epub 2009 Feb 18.
Mugusi FM, Mehta S, Villamor E, Urassa W, Saathoff E, Bosch RJ, Fawzi WW. Factors associated with mortality in HIV-infected and uninfected patients with pulmonary tuberculosis. BMC Public Health. 2009 Nov 12;9:409.
Shet A, Mehta S, Rajagopalan N, Dinakar C, Ramesh E, Samuel NM, Indumathi CK, Fawzi WW, Kurpad AV. Anemia and growth failure among HIV-infected children in India: a retrospective analysis. BMC Pediatr. 2009 Jun 16;9:37.
Sztam KA, Fawzi WW, Duggan C. Macronutrient supplementation and food prices in HIV treatment. J Nutr. 2010 Jan;140(1):213S-23S. Epub 2009 Nov 25. Review.
Tassiopoulos K, Kapiga S, Sam N, Ao TT, Hughes M, Seage GR 3rd. A case-crossover analysis of predictors of condom use by female bar and hotel workers in Moshi, Tanzania. Int J Epidemiol. 2009 Apr;38(2):552-60. Epub 2009 Jan 15.
2008
Aboud S, Msamanga G, Read JS, Mwatha A, Chen YQ, Potter D, Valentine M, Sharma U, Hoffmann I, Taha TE, Goldenberg RL, Fawzi WW. Genital tract infections among HIV-infected pregnant women in Malawi, Tanzania and Zambia. Int J STD AIDS. 2008 Dec;19(12):824-32.
Fisher, JC., Cook, PA., Sam, NE., Kapiga, SH. Patterns of alcohol use, problem drinking, and HIV infection among high-risk African women. Sex. Transm. Dis. Jun; 35(6): 537-44 (2008)
Kamo, N., Carlson, M., Brennan, RT., Earls, F. Young citizens as health agents: use of drama in promoting community efficacy for HIV/AIDS. Am. J. Public Health. Feb; 98(2): 201-4 (2008)
Kawai K, Kaaya SF, Kajula L, Mbwambo J, Kilonzo GP, Fawzi WW. Parents' and teachers' communication about HIV and sex in relation to the timing of sexual initiation among young adolescents in Tanzania. Scand J PUblic Health. November; 36(8) 879-888. (2008).
Kupka, R., Mugusi, F., Aboud, S., Msamanga, GI., Finkelstein, JL., Spiegelman, D., Fawzi, WW. Randomized, double-blind, placebo-controlled trial of selenium supplements among HIV-infected pregnant women in Tanzania: effects on maternal and child outcomes. Am. J. Clin. Nutr. Jun; 87(6): 1802-8 (2008)
Mehta, S., Manji, K.P., Young, A.M., Brown, E.R., Chasela, C., Taha, T.E., Read, J.S., Goldenberg, R.L., Fawzi, W.W. Nutritional indicators of adverse pregnancy outcomes and mother-to-child transmission of HIV among HIV-infected women. Am J Clin Nutr. Jun;87(6):1639-49. (2008)
Msisha, WM., Kapiga, S H., Earls, F J. Subramanian,-S-V. Place matters: multilevel investigation of HIV distribution in Tanzania. AIDS. Mar 30; 22(6): 741-8 (2008)
Msisha WM, Kapiga SH, Earls F, Subramanian SV. Socioeconomic status and HIV seroprevalence in Tanzania: a counterintuitive relationship. Int J Epidemiol. 2008 Dec;37(6):1297-303. Epub 2008 Sep 27.
Ramjee G, Kapiga S, Weiss S, Peterson L, Leburg C, Kelly C, Masse B; HPTN 055 Study Team. The value of site preparedness studies for future implementation of phase 2/IIb/III HIV prevention trials: experience from the HPTN 055 study. J Acquir Immune Defic Syndr. 2008 Jan 1;47(1):93-100.
Urassa W, Mugusi F, Villamor E, Msamanga G, Moshiro C, Bosch R, Saathoff E, Fawzi W. Primary antimicrobial resistance among Mycobacterium tuberculosis isolates from HIV seropositive and HIV seronegative patients in Dar es Salaam Tanzania. BMC Res Notes. 2008 Jul 31;1:58.
Villamor, E., Mugusi, F., Urassa, W., Bosch, RJ., Saathoff, E., Matsumoto, K., Meydani, SN., Fawzi, WW. A trial of the effect of micronutrient supplementation on treatment outcome, T cell counts, morbidity, and mortality in adults with pulmonary tuberculosis. J. Infect. Dis. Jun 1; 197(11): 1499-505 (2008).
Webb AL, Manji K, Fawzi WW, Villamor E. Time-independent maternal and infant factors and time-dependent infant morbidities including HIV infection, contribute to infant growth faltering during the first 2 years of life. J Trop Pediatr. 2009 Apr;55(2):83-90. Epub 2008 Aug 22.
2007
Antelman, G., Kaaya, S., Wei, R., Mbwambo, J., Msamanga, GI., Fawzi, WW., Fawzi, MC. Depressive symptoms increase risk of HIV disease progression and mortality among women in Tanzania. JAIDS. Apr 1; 44(4): 470-7
(2007)
Chatterjee, A., Bosch, R.J., Hunter, D.J., Fataki, M.R., Msamanga, G.I., Fawzi, W.W. Maternal disease stage and child undernutrition in relation to mortality among children born to HIV-infected women in Tanzania. J Acquir Immune Defic Syndr. Dec 15;46(5):599-606. (2007)
Drain, PK., Kupka, R., Msamanga, GI., Urassa, W., Mugusi, F., Fawzi, WW. C-reactive protein independently predicts HIV-related outcomes among women and children in a resource-poor setting. AIDS. Oct 1; 21(15): 2067-75 (2007)
Fawz,i W.W., Msamanga, G.I., Kupka, R., Spiegelman, D., Villamor, E., Mugusi, F., Wei, R., Hunter, D. Multivitamin supplementation improves hematologic status in HIV-infected women and their children in Tanzania. Am J Clin Nutr. May;85(5):1335-43. (2007)
Fisher JC, Bang H, Kapiga SH. The association between HIV infection and alcohol use: a systematic review and meta-analysis of African studies. Sex Transm Dis. 2007 Nov;34(11):856-63. Review.
Kantarci, S., Koulinska, IN., Aboud, S., Fawzi, WW., Villamor, E. Subclinical mastitis, cell-associated HIV-1 shedding in breast milk, and breast-feeding transmission of HIV-1. JAIDS. Dec 15; 46(5): 651-4 (2007)
Kapiga, S.H., Sam, N.E., Bang, H., Ni, Q., Ao, T.T.H., Kiwelu, I., Chiduo, S., Ndibe, U., Seage, G. III, Coplan, P., Shao, J., Rosenberg, Z.F., and Essex, M. The Role of Herpes Simplex Virus Type 2 and Other Genital Infections in the Acquisition of HIV-1 among High-Risk Women in Northern Tanzania. J. Infect. Dis. 195:1260-1269 (2007).
Kupka, R., Msamanga, G.I., Mugusi, F., Petraro, P., Hunter, D.J., Fawzi, W.W. Iron status is an important cause of anemia in HIV-infected Tanzanian women but is not related to accelerated HIV disease progression. J Nutr. Oct;137(10):2317-23. (2007)
Kupka, R., Msamanga, G.I., Xu, C., Anderson, D., Hunter, D., Fawzi, W.W. Relationship between plasma selenium concentrations and lower genital tract levels of HIV-1 RNA and interleukin type 1beta. Eur J Clin Nutr. Apr;61(4):542-7. (2007)
Larsen, U., Mlay, J., Aboud, S., Ballard, R., Sam, NE., Shao, JF., Kapiga, SH. Design of a community-based study of sexually transmitted infections/HIV and infertility in an urban area of northern Tanzania. Sex. Transm. Dis. Jan; 34(1): 20-4 (2007)
Tassiopoulos, K.K., Seage, G., III, Sam, N., Kiwelu, I., Shao, J., Ao, T.T.H., Essex, M., Coplan, P., Rosenberg, Z., Hughes, M., and Kapiga, S. Predictors of Herpes Simplex Virus Type 2 Prevalence and Incidence among Bar and Hotel Workers in Moshi, Tanzania. J. Infect. Dis. 195:493-501 (2007).
Villamor, E., Koulinska, I.N., Furtado, J., Baylin, A., Aboud, S., Manji, K., Campos, H., Fawzi, W.W. Long-chain n-6 polyunsaturated fatty acids in breast milk decrease the risk of HIV transmission through breastfeeding. Am J Clin Nutr. Sep;86(3):682-9. (2007)
Villamor, E., Msamanga, G., Saathoff, E., Fataki, M., Manji, K., Fawzi, W.W. Effects of maternal vitamin supplements on malaria in children born to HIV-infected women. Am J Trop Med Hyg.Jun;76(6):106-71. (2007)
2006
Ao, T.T., Sam, N.E., Masenga. E.J., Seage, G.R 3rd, Kapiga, S.H. Human immunodeficiency virus type 1 among bar and hotel workers in northern
Tanzania: the role of alcohol, sexual behavior, and herpes simplex virus type 2. Sex Transm Dis. Mar;33(3):163-9. (2006)
Kapiga, SH., Sam, NE., Mlay, J., Aboud, S., Ballard, RC., Shao, JF., Larsen, U. The epidemiology of HIV-1 infection in northern Tanzania: results from a community-based study. AIDS Care. May; 18(4): 379-87 (2006)
Koulinska, I.N., Villamor, E., Msamanga, G., Fawzi, W., Blackard, J., Renjifo, B., and Essex, M. Risk of HIV-1 Transmission by Breastfeeding among Mothers Infected with Recombinant and Non-recombinant HIV-1 Genotypes. Virus Res. 120:191-198 (2006).
Koulinska, I.N., Villamor, E., Chaplin, B. Msamanga, G., Fawzi, W., Renjifo, B., and Essex, M. Transmission of Cell-Free and Cell-Associated HIV-1 Through Breast-Feeding. J. Acquir. Immune Defic. Syndr. 41:93-99 (2006).
McGrath, N., Bellinger, D., Robins, J., Msamanga, G.I., Tronick, E., Fawzi, W.W. Effect of maternal multivitamin supplementation on the mental and psychomotor development of children who are born to HIV-1-infected mothers in Tanzania. Pediatrics. Feb;117(2):e216-25 (2006)
Msamanga, G., Fawzi, W., Hertzmark, E., McGrath, N., Kapiga, S., Kagoma, C., Spiegelman, D., Hunter, D. Socio-economic and demographic factors associated with prevalence of HIV infection among pregnant women in Dar es Salaam, Tanzania. East Afr Med J. Jun;83(6):311-21. (2006)
Sedgh, G., Larsen, U., Spiegelman, D., Msamanga, G., Fawzi, W.W. HIV-1 infection and fertility in Dar es Salaam, Tanzania. Afr J Reprod Health. Dec;10(3):41-52. (2006)
Tassiopoulos, K.K., Seage, G.R 3rd, Sam, N.E., Ao, T.T., Masenga, E.J., Hughes, M.D., Kapiga, S.H. Sexual behavior, psychosocial and knowledge differences between consistent, inconsistent and non-users of condoms: a study of female bar and hotel workers in Moshi, Tanzania. AIDS Behav. Jul;10(4):405-13. (2006)
Vasan, A., Renjifo, B., Hertzmark, E., Chaplin, B., Msamanga, G., Essex, M., Fawzi, W., and Hunter, D. Different Rates of Disease Progression of HIV Type 1 Infection in Tanzania Based on Infecting Subtype. Clin. Infect. Dis. 42:843-852 (2006).
Villamor, E., Aboud, S., Koulinska, I.N., Kupka, R., Urassa, W., Chaplin, B., Msamanga, G., Fawzi, W.W. Zinc supplementation to HIV-1-infected pregnant women: effects on maternal anthropometry, viral load, and early mother-to-child transmission. Eur J Clin Nutr. Jul;60(7):862-9. (2006)
Villamor, E., Kapiga, S.H., Fawzi, W.W. Vitamin A serostatus and heterosexual transmission of HIV: case-control study in Tanzania and review of the evidence. Int J Vitam Nutr Res. Mar;76(2):81-5. (2006)
Villamor, E., Saathoff, E., Mugusi, F., Bosch, R.J., Urassa, W., Fawzi, W.W. Wasting and body composition of adults with pulmonary tuberculosis in relation to HIV-1 coinfection, socioeconomic status, and severity of tuberculosis. Eur J Clin Nutr. Feb;60(2):163-71. (2006)
2005
Baylin, A., Villamor, E., Rifai, N., Msamanga, G., Fawzi, W.W. Effect of vitamin supplementation to HIV-infected pregnant women on the
micronutrient status of their infants. Eur J Clin Nutr. Aug;59(8):960-8. (2005)
Fawzi, W., Msamanga, G., Spiegelman, D., Hunter, D.J. Studies of vitamins and minerals and HIV transmission and disease progression. J Nutr. Apr;135(4):938-44. (2005)
Fawzi, W.W, Villamor, E., Msamanga, G.I., Antelman, G., Aboud, S., Urassa, W., Hunter, D. Trial of zinc supplements in relation to pregnancy outcomes, hematologic indicators, and T cell counts among HIV-1-infected women in Tanzania. Am J Clin Nutr. Jan;81(1):161-7. (2005)
Kiwelu, I.E., Koulinska, I.N., Nkya, W.M., Shao, J., Kapiga, S., Essex, M. Identification of CRF10_CD viruses among bar and hotel workers in Moshi, Northern Tanzania. AIDS Res Hum Retroviruses. Oct;21(10):897-900. (2005)
Kupka, R., Msamanga, G.I., Spiegelman, D., Rifai, N., Hunter, D.J., Fawzi, W.W. Selenium levels in relation to morbidity and mortality among children born to HIV-infected mothers. Eur J Clin Nutr. Nov;59(11):1250-8. (2005)
Merchant, A.T., Msamanga, G., Villamor, E., Saathoff, E., O'brien, M., Hertzmark, E., Hunter, D.J., Fawzi, W.W. Multivitamin supplementation of HIV-positive women during pregnancy reduces hypertension. J Nutr. Jul;135(7):1776-81. (2005)
O'Brien, M.E., Kupka, R., Msamanga, G.I., Saathoff, E., Hunter, D.J., Fawzi, W.W. Anemia is an independent predictor of mortality and immunologic progression of disease among women with HIV in Tanzania. J Acquir Immune Defic Syndr. Oct 1;40(2):219-25. (2005)
Sedgh, G., Larsen, U., Spiegelman, D., Msamanga, G., Fawzi, W.W. HIV-1 disease progression and fertility in Dar es Salaam, Tanzania. J Acquir Immune Defic Syndr. Aug 1;39(4):439-45. (2005)
Venkatesh, P.A., Bosch, R.J., McIntosh, K., Mugusi, F., Msamanga, G., Fawzi, W.W. Predictors of incident tuberculosis among HIV-1-infected women in Tanzania. Int J Tuberc Lung Dis. Oct;9(10):1105-11. (2005)
Villamor, E., Misegades, L., Fataki, M.R., Mbise, R.L., Fawzi, W.W. Child mortality in relation to HIV infection, nutritional status, and socio-economic background. Int J Epidemiol. Feb;34(1):61-8. (2005)
Villamor, E., Saathoff, E., Bosch, R.J., Hertzmark, E., Baylin, A., Manji, K., Msamanga, G., Hunter, D.J., Fawzi, W.W. Vitamin supplementation of HIV-infected women improves postnatal child growth. Am J Clin Nutr. Apr;81(4):880-8. (2005)
Villamor, E., Saathoff, E., Manji, K., Msamanga, G., Hunter, D.J., Fawzi, W.W. Vitamin supplements, socioeconomic status, and morbidity events as predictors of wasting in HIV-infected women from Tanzania. Am J Clin Nutr. Oct;82(4):857-65. (2005)
Villamor, E., Saathoff, E., Msamanga, G., O'Brien, M.E., Manji, K., Fawzi, W.W. Wasting during pregnancy increases the risk of mother-to-child HIV-1 transmission. J Acquir Immune Defic Syndr. Apr 15;38(5):622-6. (2005)
2004
Fawzi, W.W., Msamanga, G.I., Spiegelman, D., Wei, R., Kapiga, S., Villamor, E., Mwakagile,
D., Mugusi, F., Hertzmark, E., Essex, M., Hunter, D.J.
A randomized trial of multivitamin supplements and HIV disease progression and
mortality. N Engl J Med. Jul 1;351(1):23-32. (2004)
Kupka, R., Msamanga, G.I., Spiegelman, D., Morris, S., Mugusi, F., Hunter, D.J., Fawzi, W.W. Selenium status is associated with accelerated HIV disease progression among HIV-1-infected pregnant women in Tanzania. J Nutr. Oct;134(10):2556-60. (2004)
Sedgh, G., Spiegelman, D., Larsen, U., Msamanga, G., Fawzi, W.W. Breastfeeding and maternal HIV-1 disease progression and mortality. AIDS. Apr 30;18(7):1043-9. (2004)
Wei, R., Msamanga, G.I., Spiegelman, D., Hertzmark, E., Baylin, A., Manji, K., Fawzi, W.W. Association between low birth weight and infant mortality in children born to human immunodeficiency virus 1-infected mothers in Tanzania. Pediatr Infect Dis J. Jun;23(6):530-5. (2004)
Westheimer, E.F., Urassa, W., Msamanga, G., Baylin, A., Wei, R., Aboud, S., Kaaya, S., Fawzi, W.W. Acceptance of HIV testing among pregnant women in Dar-es-Salaam, Tanzania. J Acquir Immune Defic Syndr. Sep 1;37(1):1197-205. (2004)
2003
Ao, T., Sam, N., Manongi, R., Seage, G., Kapiga, S. Social and behavioural determinants of consistent condom use among hotel and bar workers in Northern Tanzania. Int J STD AIDS. Oct;14(10):688-96. (2003)
Kapiga, S.H., Sam, N.E., Shao, J.F., Masenga, E.J., Renjifo, B., Kiwelu, I.E., Manongi, R., Fawzi, W.W., Essex, M. Herpes simplex virus type 2 infection among bar and hotel workers in northern Tanzania: prevalence and risk factors. Sex Transm Dis. Mar;30(3):187-92. (2003)
Kapiga, S.H., Lugalla, J.L. Male condom use in Tanzania: results from a national survey. East Afr Med J. Apr;80(4):181-90. (2003)
Kiwelu, I.E., Renjifo, B., Chaplin, B., Sam, N., Nkya, W.M., Shao, J., Kapiga, S., Essex, M. HIV type 1 subtypes among bar and hotel workers in Moshi, Tanzania. AIDS Res Hum Retroviruses. Jan 1;19(1):57-64. (2003)
Koulinska, I., Chaplin, B., Mwakagile, D., Essex, M., and Renjifo, B. Hypermutation of HIV-1 Genomes Isolated from Infants Soon After Vertical Infection. AIDS Res. Hum. Retroviruses 19:1115-1123 (2003).
Mugusi, F.M., Rusizoka, O., Habib, N., Fawzi, W. Vitamin A status of patients presenting with pulmonary tuberculosis and asymptomatic HIV-infected individuals, Dar es Salaam, Tanzania. Int J Tuberc Lung Dis. Aug;7(8):804-7. (2003)
Renjifo, B., Chung, M., Gilbert, P., Mwakagile, D., Msamanga, G., Fawzi, W., and Essex, M. In-Utero Transmission of Quasispecies among Human Immunodeficiency Virus Type 1 Genotypes. Virology 307:278-282 (2003).
Villamor, E., Fataki, M.R., Mbise, R.L., Fawzi, W.W. Malaria parasitaemia in relation to HIV status and vitamin A supplementation among pre-school children. Trop Med Int Health. Dec;8(12):1051-61. (2003)
Villamor, E., Msamanga, G., Spiegelman, D., Peterson, K.E., Antelman, G., Fawzi, W.W. Pattern and predictors of weight gain during pregnancy among HIV-1-infected women from Tanzania. J Acquir Immune Defic Syndr. Apr 15;32(5):560-9. (2003)
2002
Fawzi, W., Msamanga, G., Spiegelman, D., Renjifo, B., Bang, H., Kapiga, S., Coley, J.,
Hertzmark, E., Essex, M., Hunter, D. Transmission of HIV-1 through breastfeeding among women in Dar es Salaam,
Tanzania. J Acquir Immune Defic Syndr. Nov 1;31(3):331-8. (2002)
Fawzi, W.W., Msamanga, G.I., Hunter, D., Renjifo, B., Antelman, G., Bang, H., Manji, K., Kapiga, S., Mwakagile, D., Essex, M., Spiegelman, D. Randomized trial of vitamin supplements in relation to transmission of HIV-1 through breastfeeding and early child mortality. AIDS. Sep 27;16 (14):1935-44. (2002)
Kaaya, S.F., Fawzi, M.C., Mbwambo, J.K., Lee, B., Msamanga, G.I., Fawzi, W. Validity of the Hopkins Symptom Checklist-25 amongst HIV-positive pregnant women in Tanzania. Acta Psychiatr Scand. Jul;106(1):9-19. (2002)
Kapiga, S.H., Lugalla, J.L. Sexual behaviour patterns and condom use in Tanzania: results from the 1996 Demographic and Health Survey. AIDS Care. Aug;14(4):455-69. (2002)
Kapiga, S.H., Sam, N.E., Shao, J.F., Renjifo, B., Masenga, E.J., Kiwelu, I.E., Manongi, R., Fawzi, W., Essex, M. HIV-1 epidemic among female bar and hotel workers in northern Tanzania: risk factors and opportunities for prevention. J Acquir Immune Defic Syndr. Apr 1;29(4):409-17. (2002)
Koulinska, I.N., Msamanga, G., Mwakagile, D., Essex, M., Renjifo, B. Common genetic arrangements among human immunodeficiency virus type 1 subtype A and D recombinant genomes vertically transmitted in Tanzania. AIDS Res Hum Retroviruses. Sep 1;18(13):947-56. (2002)
Koulinska, I., Msamanga, G., Mwakagile, D., Essex, M., and Renjifo B. Common Genetic Arrangements Among Human Immunodeficiency Virus Type 1 Subtype A and D Recombinant Genomes Vertically Transmitted in Tanzania. AIDS Res. Hum. Retroviruses 18:947-956 (2002).
Villamor, E., Msamanga, G., Spiegelman, D., Coley, J., Hunter, D.J., Peterson, K.E., Fawzi, W.W. HIV status and sociodemographic correlates of maternal body size and wasting during pregnancy. Eur J Clin Nutr. May;56(5):415-24. (2002)
2001
Antelman, G., Smith Fawzi, M.C., Kaaya, S., Mbwambo, J., Msamanga, G.I., Hunter, D.J., Fawzi,
W.W.
Predictors of HIV-1 serostatus disclosure: a prospective study among HIV-infected
pregnant women in Dar es Salaam, Tanzania. AIDS. Sep 28;15(14):1865-74. (2001)
Blackard, J.T., Renjifo, B., Fawzi, W., Msamanga, G., Mwakagile, D., Hertzmark, E., Hunter, D., Spiegelman, D., Sharghi, N., Kagoma, C., and Essex, M. HIV-1 LTR Subtype and Perinatal Transmission. Virology 287:261-265 (2001).
Coley, J.L., Msamanga, G.I., Fawzi, M.C., Kaaya, S., Hertzmark, E., Kapiga, S., Spiegelman, D., Hunter, D., Fawzi, W.W. The association between maternal HIV-1 infection and pregnancy outcomes in Dar es Salaam, Tanzania. BJOG. Nov;108(11):1125-33. (2001)
Dreyfuss, M.L., Msamanga, G.I., Spiegelman, D., Hunter, D.J., Urassa, E.J., Hertzmark, E., Fawzi, W.W. Determinants of low birth weight among HIV-infected pregnant women in Tanzania. Am J Clin Nutr. Dec;74(6):814-26. (2001)
Fawzi, W., Msamanga, G., Renjifo, B., Spiegelman, D., Urassa, E., Hashemi, L., Antelman, G., Essex, M., Hunter, D. Predictors of intrauterine and intrapartum transmission of HIV-1 among Tanzanian women. AIDS. Jun 15;15(9):1157-65. (2001)
Koulinska, I.N., Ndung'u, T., Mwakagile, D., Msamanga, G., Kagoma, C., Fawzi, W., Essex, M., Renjifo, B. A new human immunodeficiency virus type 1 circulating recombinant form from Tanzania. AIDS Res Hum Retroviruses. Mar 20;17(5):423-31. (2001)
Renjifo, B., Fawzi, W., Mwakagile, D., Hunter, D., Msamanga, G., Spiegelman, D., Garland, M., Kim, A., Chaplin, B., Hertzmarle, E., and Essex, M. Differences in Vertical Transmission Between HIV-1 Genotypes. J. Hum. Virol. 4:16-25 (2001).
Urassa, W.K., Kapiga, S.H., Msamanga, G.I., Antelman, G., Coley, J., Fawzi, W.W. Risk factors for syphilis among HIV-1 infected pregnant women in Dar es Salaam, Tanzania. Afr J Reprod Health. Dec;5(3):54-62. (2001)
2000
Blackard, J.T., Renjifo, B., Chaplin, B., Msamanga, G., Fawzi, W., Essex, M.
Diversity of the HIV-1 long terminal repeat following mother-to-child
transmission. Virology. Sep 1;274(2):402-11. (2000)
Fawzi, W.W., Msamanga, G., Hunter, D., Urassa, E., Renjifo, B., Mwakagile, D., Hertzmark, E., Coley, J., Garland, M., Kapiga, S., Antelman, G., Essex, M., Spiegelman, D. Randomized trial of vitamin supplements in relation to vertical transmission of HIV-1 in Tanzania. J Acquir Immune Defic Syndr. Mar 1;23(3):246-54. (2000)
Kapiga, S.H., Lyamuya, E.F., Vuylsteke, B., Spiegelman, D., Larsen, U., Hunter, D.J. Risk factors for HIV-1 seroprevalence among family planning clients in Dar es Salaam, Tanzania. Afr J Reprod Health. Apr;4(1):88-99. (2000)
Kapiga, S.H., Mwakagile, D., Spiegelman, D., Msamanga, G.I., Hunter, D., Fawzi, W.W. Predictors of CD4+ lymphocyte count among HIV-seropositive and HIV-seronegative pregnant women in Dar es Salaam, Tanzania. East Afr Med J.Apr;77(4):206-11. (2000)
Villamor, E., Mbise, R., Spiegelman, D., Ndossi, G., Fawzi, W.W. Vitamin A supplementation and other predictors of anemia among children from Dar Es Salaam, Tanzania. Am J Trop Med Hyg. May;62(5):590-7. (2000)
1999
Blackard, J.T., Renjifo, B.R., Mwakagile, D., Montano, M.A., Fawzi, W.W., Essex, M. Transmission of human immunodeficiency type 1 viruses with intersubtype
recombinant long terminal repeat sequences. Virology. Feb 15;254(2):220-5. (1999)
Fawzi, W.W., Mbise, R.L., Hertzmark, E., Fataki, M.R., Herrera, M.G., Ndossi, G., Spiegelman, D. A randomized trial of vitamin A supplements in relation to mortality among human immunodeficiency virus-infected and uninfected children in Tanzania. Pediatr Infect Dis J. Feb;18(2):127-33. (1999)
Fawzi, W.W., Msamanga, G.I., Spiegelman, D., Urassa, E.J., Hunter, D.J. Rationale and design of the Tanzania Vitamin and HIV Infection Trial. Control Clin Trials. Feb;20(1):75-90. (1999)
Kapiga, S.H., Msamanga, G.I., Spiegelman, D., Mwakyoma, H., Fawzi, W.W, Hunter, D.J. Risk factors for cervical squamous intraepithelial lesions among HIV-1 seropositive women in Dar es Salaam, Tanzania. Int J Gynaecol Obstet. Nov;67(2):87-94. (1999)
Renjifo, B., Gilbert, P., Chaplin, B., Vannberg, F., Mwakagile, D., Msamanga, G., Hunter, D., Fawzi, W., Essex, M. Emerging recombinant human immunodeficiency viruses: uneven representation of the envelope V3 region. AIDS. Sep 10;13(13):1613-21. (1999)
1998
Fawzi, W.W., Msamanga, G.I., Spiegelman, D., Urassa, E.J., McGrath, N., Mwakagile, D.,
Antelman, G., Mbise, R., Herrera, G., Kapiga, S., Willett, W., Hunter, D.J.
Randomised trial of effects of vitamin supplements on pregnancy outcomes and T
cell counts in HIV-1-infected women in Tanzania. Lancet. May 16;351(9114):1477-82. (1998)
Kapiga, S.H., Lyamuya, E.F., Lwihula, G.K., Hunter, D.J. The incidence of HIV infection among women using family planning methods in Dar es Salaam, Tanzania. AIDS. Jan 1;12(1):75-84. (1998)
Kapiga, S.H., Vuylsteke, B., Lyamuya, E.F., Dallabetta, G., Laga, M. Evaluation of sexually transmitted diseases diagnostic algorithms among family planning clients in Dar es Salaam, Tanzania. Sex Transm Infect. Jun;74 Suppl 1:S132-8. (1998)
Renjifo, B., Chaplin, B., Mwakagile, D., Shah, P., Vannberg, F., Msamanga, G., Hunter, D., Fawzi, W., Essex, M. Epidemic expansion of HIV type 1 subtype C and recombinant genotypes in Tanzania. AIDS Res Hum Retroviruses. May 1;14(7):635-8. (1998) No abstract available.
1996
Kapiga, S.H. Determinants of multiple sexual partners and condom use among sexually active
Tanzanians. East Afr Med J. Jul;73(7):435-42. (1996)
1995
Kapiga, S.H., Lwihula, G.K., Shao, J.F., Hunter, D.J.
Predictors of AIDS knowledge, condom use and high-risk sexual behaviour among
women in Dar-es-Salaam, Tanzania. Int J STD AIDS. May-Jun;6(3):175-83. (1995)
1994
Kapiga SH, Shao JF, Lwihula GK, Hunter DJ. Risk factors for HIV infection among women in Dar-es-Salaam, Tanzania.
J Acquir Immune Defic Syndr. 1994 Mar;7(3):301-9.
 |
| The laboratory staff in Chiang Mai, Thailand |
Over the last ten years, more than 2,400 mother-infant pairs have completed HIV/AIDS intervention trials sponsored by HAI in Thailand.
HAI has provided training for a significant percentage of Thailand's academic HIV/AIDS specialists and has established an HIV/AIDS research, training, and support network among 14 hospitals in the country. In 2000, the Thai government adopted a chemoprophylaxis regimen as the national standard that was identified by a Harvard trial.
Harvard has received awards from Thailand's Mahidol University, the City of Bangkok, and the Prime Minister of Thailand for contributions related to HIV and AIDS.
2011
Cressey TR, Urien S, Hirt D, Halue G, Techapornroong M, Bowonwatanuwong C, Leenasirimakul P, Treluyer JM, Jourdain G, Lallemant M; PHPT-3 Team. Influence of body weight on achieving indinavir concentrations within its therapeutic window in HIV-infected Thai patients receiving indinavir boosted with ritonavir. Ther Drug Monit. 2011 Feb;33(1):25-31.
2010
Collins IJ, Jourdain G, Hansudewechakul R, Kanjanavanit S, Hongsiriwon S, Ngampiyasakul C, Sriminiphant S, Technakunakorn P, Ngo-Giang-Huong N, Duong T, Le Coeur S, Jaffar S, Lallemant M; Program for HIV Prevention and Treatment Study Team. Long-term survival of HIV-infected children receiving antiretroviral therapy in Thailand: a 5-year observational cohort study. Clin Infect Dis. 2010 Dec 15;51(12):1449-57. Epub 2010 Nov 5.
Briand N, Le Coeur S, Jourdain G, Hotrawarikarn S, Sirinontakan S, Hinjiranandana T, Kanjanavanit S, Traisathit P, McIntosh K, Lallemant M; Program for HIV Prevention and Treatment Study Group. Hematological safety of perinatal exposure to zidovudine in uninfected infants born to HIV type 1-infected women in Thailand. AIDS Res Hum Retroviruses. 2010 Oct;26(10):1163-6. Epub 2010 Sep 21.
Cressey TR, Jourdain G, Rawangban B, Varadisai S, Kongpanichkul R, Sabsanong P, Yuthavisuthi P, Chirayus S, Ngo-Giang-Huong N, Voramongkol N, Pattarakulwanich S, Lallemant M; PHPT-5 Team.Pharmacokinetics and virologic response of zidovudine/lopinavir/ritonavir initiated during the third trimester of pregnancy. AIDS. 2010 Sep 10;24(14):2193-200.
Jourdain G, Wagner TA, Ngo-Giang-Huong N, Sirirungsi W, Klinbuayaem V, Fregonese F, Nantasen I, Techapornroong M, Halue G, Nilmanat A, Wittayapraparat P, Chalermpolprapa V, Pathipvanich P, Yuthavisuthi P, Frenkel LM, Lallemant M; Program for HIV Prevention and Treatment (PHPT) Study Group.Association between detection of HIV-1 DNA resistance mutations by a sensitive assay at initiation of antiretroviral therapy and virologic failure. Clin Infect Dis. 2010 May 15;50(10):1397-404.
Wagner TA, Kress CM, Beck I, Techapornroong M, Wittayapraparat P, Tansuphasawasdikul S, Jourdain G, Ngo-Giang-Huong N, Lallemant M, Frenkel LM. Detection of HIV-1 drug resistance in women following administration of a single dose of nevirapine: comparison of plasma RNA to cellular DNA by consensus sequencing and by oligonucleotide ligation assay. J Clin Microbiol. 2010 May;48(5):1555-61. Epub 2010 Feb 24.
Lallemant M, Ngo-Giang-Huong N, Jourdain G, Traisaithit P, Cressey TR, Collins IJ, Jarupanich T, Sukhumanant T, Achalapong J, Sabsanong P, Chotivanich N, Winiyakul N, Ariyadej S, Kanjanasing A, Ratanakosol J, Hemvuttiphan J, Kengsakul K, Wannapira W, Sittipiyasakul V, Pornkitprasarn W, Liampongsabuddhi P, McIntosh K, Van Dyke RB, Frenkel LM, Koetsawang S, Le Coeur S, Kanchana S; PHPT-4 Study Team. Efficacy and safety of 1-month postpartum zidovudine-didanosine to prevent HIV-resistance mutations after intrapartum single-dose nevirapine. Clin Infect Dis. 2010 Mar 15;50(6):898-908.
Ngo-Giang-Huong N, Jourdain G, Sirirungsi W, Decker L, Khamduang W, Le Coeur S, Sirinontakan S, Somsamai R, Pagdi K, Hemvuttiphan J, McIntosh K, Barin F, Lallemant M. Human immunodeficiency virus-hepatitis C virus co-infection in pregnant women and perinatal transmission to infants in Thailand. Int J Infect Dis. 2010 Jul;14(7):e602-7. Epub 2010 Jan 3.
Cressey TR, Lallemant M. Pharmacogenomics and the prevention of mother-to-child transmission of HIV. Pharmacogenomics. 2010 Jan;11(1):1-4. No abstract available.
2009
Chantarangsu S, Cressey TR, Mahasirimongkol S, Capparelli E, Tawon Y, Ngo-Giang-Huong N, Jourdain G, Lallemant M, Chantratita W.
Influence of CYP2B6 polymorphisms on the persistence of plasma nevirapine concentrations following a single intra-partum dose for the prevention of mother to child transmission in HIV-infected Thai women. J Antimicrob Chemother. 2009 Dec;64(6):1265-73. Epub 2009 Oct 6.
Traisathit P, Mary JY, Le Coeur S, Thantanarat S, Jungpichanvanich S, Pornkitprasarn W, Gomutbutra V, Matanasarawut W, Wannapira W, Lallemant M. Risk factors of preterm delivery in HIV-infected pregnant women receiving zidovudine for the prevention of perinatal HIV. J Obstet Gynaecol Res. 2009 Apr;35(2):225-33.
McIntyre J, Lallemant M. Recent advances in the prevention of mother-to-child transmission. Curr Opin HIV AIDS. 2008 Mar;3(2):136-8. No abstract available.
Briand N, Pornprasert S, Ngo-Giang-Huong N, Galactéros F, Pissard S, Tatu T, Sanguansermsri T, Jourdain G, Lallemant M, Le Coeur S.Perinatal zidovudine prophylaxis in HIV type-1-infected pregnant women with thalassaemia carriage in Thailand. Antivir Ther. 2009;14(1):117-22.
Samleerat T, Thenin S, Jourdain G, Ngo-Giang-Huong N, Moreau A, Leechanachai P, Ithisuknanth J, Pagdi K, Wannarit P, Sangsawang S, Lallemant M, Barin F, Braibant M. Maternal neutralizing antibodies against a CRF01_AE primary isolate are associated with a low rate of intrapartum HIV-1 transmission. Virology. 2009 May 10;387(2):388-94. Epub 2009 Mar 20.
Pornprasert S, Mary JY, Faye A, Leechanachai P, Limtrakul A, Rugpao S, Sirivatanapa P, Gomuthbutra V, Matanasaravoot W, Le Coeur S, Lallemant M, Barré-Sinoussi F, Menu E, Ngo-Giang-Huong N; ANRS 1267 study team and HIV-1 PMTCT-PlaNet. Higher placental anti-inflammatory IL-10 cytokine expression in HIV-1 infected women receiving longer zidovudine prophylaxis associated with nevirapine. Curr HIV Res. 2009 Mar;7(2):211-7.
Cailhol J, Jourdain G, Coeur SL, Traisathit P, Boonrod K, Prommas S, Putiyanun C, Kanjanasing A, Lallemant M; Perinatal HIV Prevention Trial Group. Association of low CD4 cell count and intrauterine growth retardation in Thailand. J Acquir Immune Defic Syndr. 2009 Apr 1;50(4):409-13.
2008
Ngo-Giang-Huong N, Khamduang W, Leurent B, Collins I, Nantasen I, Leechanachai P, Sirirungsi W, Limtrakul A, Leusaree T, Comeau AM, Lallemant M, Jourdain G.Early HIV-1 diagnosis using in-house real-time PCR amplification on dried blood spots for infants in remote and resource-limited settings. J Acquir Immune Defic Syndr. 2008 Dec 15;49(5):465-71.
McIntyre J, Lallemant M. The prevention of mother-to-child transmission of HIV: are we translating scientific success into programmatic failure? Curr Opin HIV AIDS. 2008 Mar;3(2):139-45.
Samleerat T, Braibant M, Jourdain G, Moreau A, Ngo-Giang-Huong N, Leechanachai P, Hemvuttiphan J, Hinjiranandana T, Changchit T, Warachit B, Suraseranivong V, Lallemant M, Barin F. Characteristics of HIV type 1 (HIV-1) glycoprotein 120 env sequences in mother-infant pairs infected with HIV-1 subtype CRF01_AE. J Infect Dis. 2008 Sep 15;198(6):868-76.
Cressey TR, Green H, Khoo S, Treluyer JM, Compagnucci A, Saidi Y, Lallemant M, Gibb DM, Burger DM; Paediatric European Network for Treatment of AIDS II Study Group. Plasma drug concentrations and virologic evaluations after stopping treatment with nonnucleoside reverse-transcriptase inhibitors in HIV type 1-infected children. Clin Infect Dis. 2008 May 15;46(10):1601-8.
2007
Arvold, N.D., Ngo-Giang-Huong, N., McIntosh, K., Suraseranivong, V., Warachit, B.,
Piyaworawong, S., Changchit, T., Lallemant, M., Jourdain, G.; Perinatal HIV Prevention
Trial (PHPT-1), Thailand. Maternal HIV-1 DNA load and mother-to-child transmission. AIDS Patient Care STDS. Sep 21(9):638-43 (2007)
Cressey TR, Nangola S, Tawon Y, Pattarawarapan M, Lallemant M, Tayapiwatana C. Immunochromatographic strip test for rapid detection of nevirapine in plasma samples from human immunodeficiency virus-infected patients. Antimicrob Agents Chemother. 2007 Sep;51(9):3361-3. Epub 2007 Jul 2.
Jourdain, G., Mary, JY., Coeur, SL., Ngo-Giang-Huong, N., Yuthavisuthi, P., Limtrakul, A., Traisathit, P., McIntosh, K., Lallemant, M. Risk Factors for In Utero or Intrapartum Mother-to-Child Transmission of Human Immunodeficiency Virus Type 1 in Thailand. J.Infect. Dis. Dec 1; 196(11): 1629-36 (2007)
2006
Barin F, Jourdain G, Brunet S, Ngo-Giang-Huong N, Weerawatgoompa S, Karnchanamayul W, Ariyadej S, Hansudewechakul R, Achalapong J, Yuthavisuthi P, Ngampiyaskul C, Bhakeecheep S, Hemwutthiphan C, Lallemant M; Perinatal HIV Prevention Trial Group. Revisiting the role of neutralizing antibodies in mother-to-child transmission of HIV-1. J Infect Dis. 2006 Jun 1;193(11):1504-11. Epub 2006 Apr 21.
Briand N, Lallemant M, Jourdain G, Techapalokul S, Tunthanathip P, Suphanich S, Chanpoo T, Traisathit P, McIntosh K, Le Coeur S. Haematological safety of perinatal zidovudine in pregnant HIV-1-infected women in Thailand: secondary analysis of a randomized trial. PLoS Clin Trials. 2007 Apr 27;2(4):e11.
Briand, N., Le-Coeur, S., Traisathit, P., Karnchanamayul, V., Hansudewechakul, R., Ngampiyasakul, C., Bhakeecheep, S., Ithisukanan, J., Hongsiriwon, S., McIntosh, K., Lallemant, M. Growth of human immunodeficiency virus-uninfected children exposed to perinatal zidovudine for the prevention of mother-to-child human immunodeficiency virus transmission. Pediatr. Infect. Dis. J. Apr; 25(4): 325-32 (2006)
Cressey TR, Lallemant M. Pharmacogenetics of antiretroviral drugs for the treatment of HIV-infected patients: an update. Infect Genet Evol. 2007 Mar;7(2):333-42. Epub 2006 Oct 11. Review.
Cressey TR, Leenasirimakul P, Jourdain G, Tawon Y, Sukrakanchana PO, Lallemant M. Intensive pharmacokinetics of zidovudine 200 mg twice daily in HIV-1-infected patients weighing less than 60 kg on highly active antiretroviral therapy. J Acquir Immune Defic Syndr. 2006 Jul;42(3):387-9. No abstract available.
Traisathit, P., Le Coeur, S., Mary, J.Y., Kanjanasing, A., Lamlertkittikul, S., Lallemant, M. Gestational age determination and prevention of HIV perinatal transmission. Int. J. Gynaecol. Obstet. Feb;92(2):176-80 (2006)
2004
Lallemant, M., Jourdain, G., Le Coeur, S., Mary, J.Y., Ngo-Giang-Huong, N., Koetsawang, S.,
Kanshana, S., McIntosh, K., Thaineua, V. Perinatal HIV Prevention Trial (Thailand)
Investigators.
Single-dose perinatal nevirapine plus standard zidovudine to prevent
mother-to-child transmission of HIV-1 in Thailand. N Engl J Med. Jul 15;351(3):217-28 (2004)
2002
Talawat, S., Dore, G.J., Le Coeur, S., Lallemant, M. Infant feeding practices and attitudes among women with HIV infection in northern
Thailand. AIDS Care. Oct;14(5):625-31 (2002)
2000
Chang, S.Y., Vithayasai, V., Vithayasai, P., Auewarakul, P., Essex, M., and Lee, T.H. HIV-1 Subtype E Envelope Recombinant Peptides Containing Naturally Immunogenic Epitopes. J. Infect. Dis. 182: 442-450 (2000).
Lallemant, M., Jourdain, G., Le Coeur, S., Kim, S., Koetsawang, S., Comeau, A.M., Phoolcharoen, W., Essex, M., McIntosh, K., Vithayasai, V. A trial of shortened zidovudine regimens to prevent mother-to-child transmission of human immunodeficiency virus type 1. Perinatal HIV Prevention Trial (Thailand) Investigators. N Engl J Med. Oct 5;343(14):982-91 (2000).
1999
Chang, S.Y., Sutthent, R., Auewarakul, P., Apichartpiyakul, C., Essex, M., Lee, T.H. Differential Stability of the mRNA Secondary Structures in the Frameshift Site of Various HIV-1 Viruses. AIDS Res. Hum. Retroviruses, 15:1591-1596 (1999).
1998
Lallemant, M., McIntosh, K., Jourdain, G., Le Coeur, S., Vithayasai, V., Lee, T.H., Hammer,
S., Prescott, N., Essex, M.
Ethics of placebo-controlled trials of zidovudine to prevent the perinatal
transmission of HIV in the Third World.
N Engl J Med. Mar 19;338(12):839-40; author reply 840-1 (1998)
1996
Soto-Ramirez, L.E., Renjifo, B., McLane, M.F., Marlink, R., O'Hara, C., Sutthent, R., Wasi,
C., Vithayasai, P., Vithayasai, V., Apichartpiyakul, C., Auewarakul, P., Peña Cruz, V., Chui,
D.S., Osathanondh, R., Mayer, K., Lee, T.H., Essex, M.
HIV-1 Langerhans' cell tropism associated with heterosexual transmission of HIV. Science. Mar 1;271(5253):1291-3 (1996)
1995
Lalleman, M., Le Coeur, S., McIntosh, K., Brennan, T., Gelber, R., Lee, T.H., Hammer, S.,
Essex, M., Vithayasai, V., Sirivatanapa, P. AZT trial in Thailand.
Science. Nov 10;270(5238):899-900. (1995)
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| Max Essex and Shain Lockman |
HAI pursues innovative research concerning the pathogenesis of the AIDS virus, the treatment of HIV/AIDS, and the dynamics of the epidemic. Our core esearh labs are located at the Harvard School of Public Health in Boston.
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